器官移植2025，Vol.16Issue(2)：202-207,6.DOI:10.12464/j.issn.1674-7445.2025064
肝癌肝移植适应证的科学演进
Scientific evolution of indications for liver transplantation in hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma(HCC)is a highly prevalent malignant tumor worldwide and also the main indication for liver transplantation in China.The refined classification of transplant recipients has driven the evolution of indications for liver transplantation in HCC and is key to achieving precise liver transplantation.Tumor number and size have always been important clinical parameters limiting the eligibility of transplant recipients.The development of single-cell and spatial transcriptomics has further revealed the spatiotemporal heterogeneity of HCC.The incorporation of molecular markers into the criteria for liver transplantation in HCC represents a milestone.A classification system based on dual molecular markers can expand the pool of suitable candidates for liver transplantation while ensuring therapeutic efficacy.In recent years,the comprehensive diagnosis and treatment model for HCC represented by immunotherapy has made significant progress.The pre-transplant downstaging treatment system has become increasingly mature,allowing more patients who were previously unsuitable for transplantation to become eligible.The rise of artificial intelligence technology has also provided new tools for patient screening,classification,prognostic evaluation,and personalized treatment,further promoting the precision of liver transplantation in HCC.Therefore,this article reviews the scientific evolution of indications for liver transplantation in HCC and the role of artificial intelligence in revolutionizing the outcomes of liver transplantation for HCC patients,with the aim of benefiting more patients with HCC.关键词
肝癌/肝移植/适应证/甲胎蛋白/维生素K缺乏或拮抗剂诱导的蛋白-Ⅱ/门静脉癌栓/复发/人工智能Key words
Hepatocellular carcinoma/Liver transplantation/Indication/Alpha-fetoprotein/Protein induced by vitamin K absence or antagonist-Ⅱ/Portal vein tumor thrombus/Recurrence/Artificial intelligence分类
临床医学引用本文复制引用
沈未,鲁迪,徐骁..肝癌肝移植适应证的科学演进[J].器官移植,2025,16(2):202-207,6.基金项目
国家自然科学基金重大研究计划(92159202) （92159202）
浙江省科技厅"尖兵领雁+X"研发攻关计划(2024C03051) （2024C03051）
国家中医药综合改革示范区中医药科技共建项目(GZY-KJS-ZJ-2025-002) （GZY-KJS-ZJ-2025-002）
