器官移植2025，Vol.16Issue(2)：315-321,7.DOI:10.12464/j.issn.1674-7445.2024304
铁死亡在急性肾损伤中的分子机制及治疗靶点研究进展
Research progress on the molecular mechanism and therapeutic targets of ferroptosis in acute kidney injury
摘要
Abstract
Acute kidney injury(AKI)is one of the most common and severe nephropathy syndromes in clinical practice and also one of the most common serious complications after organ transplantation,with high incidence and fatality.Iron is an essential trace element in the body.Ferroptosis is a form of programmed cell death induced by the accumulation of iron-mediated lipid peroxidation,and its occurrence is closely related to iron metabolism,lipid metabolism,amino acid metabolism and multiple signaling pathways.Recent studies have shown that ferroptosis plays a key role in the occurrence and development of AKI and provides therapeutic targets for AKI.This article summarizes the regulatory mechanism of ferroptosis and its role in AKI,as well as the compounds that play an important role in the prevention and treatment of AKI by inhibiting ferroptosis,providing new ideas for the future treatment and research of AKI.关键词
急性肾损伤/铁死亡/器官移植/氧化应激/氨基酸代谢/肾病综合征/脂质过氧化/程序性细胞死亡Key words
Acute kidney injury/Ferroptosis/Organ transplantation/Oxidative stress/Amino acid metabolism/Nephropathy syndrome/Lipid peroxidation/Programmed cell death分类
临床医学引用本文复制引用
张阳,何繁漪,孙孔春,杨瑞,余学志,张玲,陈瑞祥,沈报春..铁死亡在急性肾损伤中的分子机制及治疗靶点研究进展[J].器官移植,2025,16(2):315-321,7.基金项目
云南省本科高校教育教学改革研究项目(JG2023001) （JG2023001）
云南省天然药物重点实验室开放基金课题项目(7012401020107) （7012401020107）
昆明医科大学一流学科团队项目(2024XKTDTS14) （2024XKTDTS14）
