摘要
Abstract
Objective:To investigate the effect of Donepezil combined with Dihydroergotoxine Methanesulfonate in the treatment of elderly patients with vascular dementia(VD).Methods:A total of 98 patients with senile VD treated in Huaiji People's Hospital from January 2022 to January 2024 were selected as the study objects,and were randomly divided into an experimental group and a control group,with 49 cases in each group.Both groups received conventional treatment,on this basis,the control group was treated with Donepezil,and the experimental group was treated with donepezil combined with Dihydroergotoxine Methanesulfonate.Both groups were treated 8 weeks.The quality of life,cerebral hemodynamic indexes,oxidative stress indexes,hemorheology indexes and the occurrence of adverse reactions were compared between the two groups.Results:After treatment,the scores of Daily Living Ability Rating Scale,Monreal Cognitive Assessment Scale in the experimental groups were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the mean middle cerebral artery flow velocity in the experimental group was more fast than the control group pulsatility index levels in the experimental group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the Superoxide dismutase level of the experimental group was higher than that of the control group,while the homocysteine,central nervous system-specific protein-β levels were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of hematocrit,fibrinogen,mid-range whole blood viscosity,low-range whole blood viscosity in the experimental group was lower than the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 10.20%,which was slightly lower than 12.24%in the control group,but there was no statistical significance between the two groups(P>0.05).Conclusion:Donepezil combined with Dihydroergotoxine Methanesulfonate has an ideal effect in the treatment of elderly patients with VD,which can improve their quality of life,cognitive function and the level of hemorheology and cerebral hemodynamics,and does not increase the probability of adverse reactions,has high clinical application value.关键词
老年性血管性痴呆/甲磺酸二氢麦角胺/认知功能Key words
Elderly vascular dementia/Dihydroergotoxine methanesulfonate/Cognitive function分类
医药卫生
