摘要
Abstract
Objective:To analyze the effects of Sackubactril Valsartan on myocardial injury markers and cardiac function in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods:A total of 70 patients with AMI who underwent PCI treatment in Rizhao Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected as the study objects,and were divided into a control group and a study group according to random number table method,with 35 cases in each group.The control group was treated with Valsartan,and the study group was treated with Sakubatril Valsartan.Both groups were treated for 4 months.The clinical efficacy,myocardial injury markers,cardiac function indexes and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 94.29%,which was higher than 74.29%of the control group,the difference was statistically significant(P<0.05).After treatment,troponin I,creatine kinase isoenzyme,brain natriuretic peptide,left ventricular end-diastolic diameter and left ventricular end-systolic diameter in both groups were lower than before treatment,and the study group were lower than the control group,left ventricular ejection fraction in both groups were higher than before treatment,and the study group was higher than the control group,the difference were statistically significant(P<0.05).The incidence of adverse reactions was 11.43%and 17.14%,respectively,with no statistical significance between the two groups(P>0.05).Conclusion:After PCI,the treatment of patients with AMI with Sackubactril Valsartan can obtain good efficacy,effectively reduce the degree of myocardial injury and improve cardiac function,and has a certain degree of safety.关键词
急性心肌梗死/沙库巴缬沙坦/心肌损伤标志物/心功能Key words
Acute myocardial infarction/Sakuba Valsartan/Myocardial injury markers/Cardiac function分类
医药卫生
