四川中医2025，Vol.43Issue(2)：192-197,6.
不同时机介入醒脑开窍针刺法对急性脑梗死的效果及炎症因子和VEGF的影响
The effect of xinnao kaiqiao acupuncture at different interventions on acute cerebral infarction and its impact on in-flammatory factors and VEGF
摘要
Abstract
Objective:To observe the clinical effects of different timing interventions of Xinnao Kaiqiao acupuncture on pa-tients with Acute Cerebral Infarction(ACI).Methods:ACI inpatients who attended our hospital and collaborating units within 24 hours of the onset of the disease from March 2021 to December 2022 were selected and digitally randomized 1∶1 into a control group and an observation group.Both groups received the same basic treatment,and the observation group was intervened within 24 hours of the onset of ACI,while the control group was intervened after 72 hours of the onset of ACI,using the National Insti-tutes of Health Stroke Scale(NIHSS),the Barthel Index(BI),the Modified Rankin Scale(Modified).The National Institutes of Health Stroke Scale(NIHSS),BI Index(Barthel Index),Modified Rankin Scale(mRS),and serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),vascular endothelial growth factor(VEGF),and other factors were used.Vascular En-dothelial Growth Factor(VEGF)indicators to assess the clinical efficacy.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The NIHSS,mRS and BI of patients in both groups im-proved after treatment compared with those at admission,and the observation group was better than the control group(P<0.05);the serum TNF-α and IL-6 levels in the observation group were lower than those in the control group at 14 days of treatment(P<0.05);the VEGF level in the observation group was significantly higher than that in the control group after treatment(P<0.05);the proportion of mRS scores 0～1 was higher in the observation group than in the control group at 3-month follow-up.Conclusion:The 24-hour intervention of Xinnao Kaiqiao acupuncture method for treating ACI patients can effectively improve clinical symptoms,reduce neurological deficits,improve the patients'ability to take care of themselves in daily life,and reduce the 3-month disability rate.关键词
醒脑开窍针刺法/急性脑梗死/炎症因子/VEGFKey words
Xinnao Kaiqiao acupuncture/Acute cerebral infarct/inflammatory factor/VEGF分类
医药卫生引用本文复制引用
刘姗,白雪,陆亮亮,易兴阳,谢娟,卿婷,蹇睿..不同时机介入醒脑开窍针刺法对急性脑梗死的效果及炎症因子和VEGF的影响[J].四川中医,2025,43(2):192-197,6.基金项目
四川省中医药管理局科技项目(编号:2021MS180). （编号:2021MS180）
