生物医学工程研究2025，Vol.44Issue(1)：37-45,9.DOI:10.19529/j.cnki.1672-6278.2025.01.06
基于默里定律的微血管网络芯片中的血栓行为研究
Research on thrombus behavior in microfluidic chip mimicking microvascular network based on Murray's law
张亚磊 1常丽芸 1耿晋发 1陶玲 1李韪韬 1杨雅敏1
作者信息
- 1. 南京航空航天大学 自动化学院,南京 211100
- 折叠
摘要
Abstract
To study the formation and evolution of microvascular embolisms under different flow conditions and their effects on blood flow distribution,we designed and fabricated a microvascular chip based on Murray's law.Firstly,using microfluidic technology,a dynamic blood flow environment simulating physiological conditions was established.Then laser speckle contrast imaging was em-ployed to obtain real-time blood flow field distributions.Finally,by analyzing the dynamic behavior of thrombus emboli and their im-pact on blood flow distribution,combined with hemodynamic simulation results,the role of hemodynamic factors on embolization was revealed.The results showed that microvascular bifurcation vertices,where blood flow velocity changed and wall shear stress decreased,tended to facilitate thrombus accumulation and growth.When emboli reached a critical size,they might detach and cause mechanical occlusion in downstream branches.Although collateral circulation could maintain the stability of outlet flow velocity in the case of in-complete obstruction,increased flow velocity in collateral vessels could still lead to vascular wall damage and impair local tissue blood exchange efficiency.This research provides a novel technical platform for investigating the mechanisms of microvascular embolism,and holds potential clinical value for the treatment and prevention of microvascular thrombosis.关键词
微血管芯片/默里定律/微血管栓塞/血流动力学/激光散斑衬比成像Key words
Microvascular chip/Murray's law/Microvascular embolism/Hemodynamics/Laser speckle contrast imaging分类
医药卫生引用本文复制引用
张亚磊,常丽芸,耿晋发,陶玲,李韪韬,杨雅敏..基于默里定律的微血管网络芯片中的血栓行为研究[J].生物医学工程研究,2025,44(1):37-45,9.
