药学研究2025，Vol.44Issue(2)：155-164,10.DOI:10.13506/j.cnki.jpr.2025.02.010
细胞膜纳米囊泡用于肿瘤疫苗的研究进展
Research advances on cellular membrane nanovesicles for tumor vaccines
摘要
Abstract
In recent years,breakthroughs have been made in tumor immunotherapy.Tumor vaccines can overcome immunosuppression by enhancing immunogenicity,thereby activating immunity to recognize and kill tumor cells,which is a promising immunotherapy modality.Biomimetic cellular membrane nanovesicles with the advantages of tumor specific targeting,prolonged half-life and immune activation effects have potential to flourish the design of tumor vaccines.In this review,we summarized the recent progresses of various cellular membrane nanovesicles in the application of tumor vaccines,discussed their characteristics,preparation,characterization and modification methods,and analyzed the challenges in clinical application.关键词
肿瘤免疫治疗/肿瘤疫苗/细胞膜纳米囊泡/药物递送系统Key words
Tumor immunotherapy/Tumor vaccines/Cellular membrane nanovesicles/Drug delivery system分类
临床医学引用本文复制引用
赵佳凝,马婷婷,况小勤,郝茗羽,李春佳雨,涂家生,孙春萌,吴彦萍,陈芊..细胞膜纳米囊泡用于肿瘤疫苗的研究进展[J].药学研究,2025,44(2):155-164,10.基金项目
国家自然科学基金青年项目(No.82303820) （No.82303820）
