药学研究2025，Vol.44Issue(2)：170-178,9.DOI:10.13506/j.cnki.jpr.2025.02.012
枸杞子及其活性成分改善神经退行性疾病的作用机制
Mechanisms of wolfberry and its active components for improving neurodegenerative diseases
摘要
Abstract
Neurodegenerative diseases(ND)are a class of diseases that lead to neurological dysfunction due to degeneration and loss of central neurons,including Alzheimer's disease(AD),Parkinson's disease(PD),Huntington's disease(HD),etc.These diseases are directly related to age and progressively worsen over time.The pathogenesis of ND is complex and difficult to elucidate,and drug development is difficult and challenging.With the acceleration of the aging process of the global population,the number of patients with ND is increasing rapidly.There are more than 55 million people suffering from AD in the world,and it is estimated that the number of patients will increase to 78 million by 2030.The number of PD patients exceeds 3 million in China,and it is expected to surge to about 5 million in 2030.This has caused a heavy social burden.Traditional Chinese medicine and its natural products are a huge treasure trove of safe and effective anti-ND.Among them,wolfberry has health care effects such as anti-oxidation,immune regulation,and neuroprotection.Therefore,it is listed as one of the tonic traditional Chinese medicines approved by the Ministry of Health of PRC and is a famous and precious Chinese medicinal material.In recent years,a large number of studies have found that wolfberry and related active substances have potential medicinal value in improving ND.This paper focused on the active ingredients of wolfberry,such as wolfberry polysaccharides,flavonoids and alkaloids.It reviewed the progress of wolfberry in the pharmacological research of ND at home and abroad,and summarizes and discusses the anti-ND mechanism and potential targets of the active ingredients of wolfberry,providing a scientific basis for the development and application of wolfberry as an anti-ND drug or functional health product.关键词
枸杞子/枸杞多糖/神经退行性疾病/阿尔茨海默病/帕金森病Key words
Lycium barbarum L./Lycium barbarum polysaccharides/Neurodegenerative disease/Alzheimer's disease/Parkinson's disease分类
医药卫生引用本文复制引用
石雅丽,孙洁,黄丰,孙赟,段文君,何蓉蓉..枸杞子及其活性成分改善神经退行性疾病的作用机制[J].药学研究,2025,44(2):170-178,9.基金项目
国家自然科学基金项目(No.82274123) （No.82274123）
宁夏回族自治区重点研发计划项目(No.2024BBF01004) （No.2024BBF01004）
广东省基础与应用基础研究基金项目(No.2023B1515020066、2023B0303000004、2023A1515110306) （No.2023B1515020066、2023B0303000004、2023A1515110306）
中国博士后科学基金项目(No.2023M731326) （No.2023M731326）
广州市疾病易感性与中医药防治重点实验室(No.2024A03J090) （No.2024A03J090）
中医药国际化广东省粤港澳高校联合实验室(No.2023LSYS002) （No.2023LSYS002）
中央高校基本科研业务费专项资金项目(No.21623116) （No.21623116）
