摘要
Abstract
Objective To observe the clinical efficacy of Tong Fu Tiao Shen needling in treating constipation-predominant irritable bowel syndrome(IBS-C)and its impact on the patient's serum levels of diamine oxidase(DAO)and D-lactate(D-LA).Method Forty IBS-C patients were randomized into a treatment group and a control group,with 20 cases in each group.The treatment group was intervened by Tong Fu Tiao Shen needling,and the control group received acupuncture at sham points near the real points.The two groups were observed for the component and general scores of irritable bowel syndrome symptom severity scale(IBS-SSS)before treatment,after 1 treatment course,after the treatment,and at follow-up;the serum levels of DAO and D-LA were detected before and after the treatment.The clinical efficacy was compared between the two groups.Result After 1 treatment course,the IBS-SSS component scores of abdominal pain severity and number of days of abdominal pain and IBS-SSS total score dropped compared to the baseline in the treatment group(P＜0.05);the control group had a decrease in the IBS-SSS total score(P＜0.05).After the treatment,the IBS-SSS component and total scores dropped in both groups compared to those before treatment and after 1 treatment course(P＜0.05).In the treatment group,the IBS-SSS total and component scores increased at the follow-up compared to those after the treatment(P＜0.05),and the scores of abdominal pain severity and satisfaction with bowel habits and the IBS-SSS total score were lower compared to those before the treatment(P＜0.05).In the control group,the IBS-SSS component scores of abdominal pain severity,number of days of abdominal pain,abdominal tightness severity,and satisfaction with bowel habits and the IBS-SSS total score were higher at the follow-up compared to those after the treatment(P＜0.05),and the component and total scores had no significant differences compared to those before treatment(P＞0.05).The IBS-SSS component scores of abdominal pain severity,number of days of abdominal pain,and satisfaction with bowel habits and the total score were lower in the treatment group than in the control group after the treatment and at the follow-up(P＜0.05).The serum levels of DAO and D-LA decreased after the treatment in both groups compared to the baseline and were lower in the treatment group than in the control group,showing statistical significance(P＜0.05).The total effective rate was 85.0%in the treatment group,higher than 25.0%in the control group,and the difference was statistically significant(P＜0.05).Conclusion Tong Fu Tiao Shen needling is effective in treating IBS-C,and the mechanism may be associated with down-regulating the serum levels of DAO and D-LA.关键词
肠易激综合征/便秘/针刺疗法/二胺氧化酶/D-乳酸Key words
Irritable bowel syndrome/Constipation/Acupuncture therapy/Diamine oxidase/D-lactate分类
医药卫生
