摘要
Abstract
Objective To observe the clinical efficacy of acupuncture combined with hyperbaric oxygen in the treatment of post-traumatic cognitive dysfunction.Method Seventy-four patients with postoperative cognitive dysfunction after traumatic brain injury were divided into a control group and a trial group according to the random number table method,with 37 patients in each group.Both groups were treated with conventional therapy,while the control group was treated with hyperbaric oxygen therapy and the trial group was treated with acupuncture combined with hyperbaric oxygen therapy.Comparison of extended Glasgow outcome scale(EGOS),Barthel index(BI),mini-mental state examination(MMSE),functional independence measure(FIM),serum brain-derived neurotrophic factor(BDNF)and glial fibrillary acidic protein(GFAP)levels were performed in the two groups before and after treatment.Result The EGOS and BI scores of both groups increased after treatment,and the differences were statistically significant(P＜0.05);the EGOS and BI scores of the trial group were higher than those of the control group,and the differences were statistically significant(P＜0.05).The MMSE and FIM scores increased in both groups after treatment,and the difference was statistically significant(P＜0.05);the MMSE and FIM scores were higher in the trial group than in the control group after treatment,and the difference was statistically significant(P＜0.05).The serum BDNF level increased and GFAP level decreased in both groups after treatment,and the difference was statistically significant(P＜0.05);the serum BDNF level in the trial group was higher than that of the control group,and GFAP level in the trial group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion On the basis of conventional treatment,acupuncture combined with hyperbaric oxygen can significantly improve the cognitive ability of post-traumatic patients,improve the quality of survival,can effectively improve the expression of relevant cytokines,the clinical efficacy is remarkable.关键词
针刺疗法/针药并用/高压氧/脑损伤,创伤性/认知障碍Key words
Acupuncture therapy/Acupuncture-medication combined/Hyperbaric oxygen/Brain Injuries,Traumatic/Cognitive impairment分类
医药卫生
