世界科学技术-中医药现代化2025，Vol.27Issue(2)：321-328,8.DOI:10.11842/wst.20240628003
脂质组学在糖尿病肾病研究中的应用进展
Application Progress of Lipidomics in Diabetic Nephropathy
摘要
Abstract
Diabetic nephropathy(DN)is a chronic complication that leads to the high mortality of diabetes mellitus(DM)patients.Many researchers are devoted to the diagnosis,etiology,process and molecular mechanism of treatment of DN.At present,the regulation of small molecular lipids on renal function and the role in the pathogenesis of DN are gradually becoming clear,and lipidomics has also become a powerful tool in DN research.DN is characterised by disorders of lipid metabolism,and lipidomics plays an important role in the characterisation of lipid metabolic profiles,diagnosis,mechanistic investigation and treatment of DN because of its unique relevance.But at the same time,the lipids in the body are complex,which brings great challenges to the detection and analysis of lipids.In the future,multidisciplinary crossover and multi-omics association is the direction of lipidomics breakthrough.This article outlines the progress of the application of lipidomics in DN research strategies,lipid metabolic profiling,early diagnosis,drug efficacy and mechanism exploration,and histological co-analysis,and further discusses the opportunities and challenges of the future application of lipidomics in DN,with the aim of providing a clear picture of the current status of the research and the prospects for researchers in the relevant directions.关键词
糖尿病肾病/糖尿病/脂质组学/生物标志物/应用进展Key words
Diabetic nephropathy/Diabetes mellitus/Lipidomics/Biomarkers/Application progresss分类
医药卫生引用本文复制引用
董政委,杨康,李遇伯,赵换..脂质组学在糖尿病肾病研究中的应用进展[J].世界科学技术-中医药现代化,2025,27(2):321-328,8.基金项目
河南省卫生健康委国家中医临床研究基地科研专项(2022JDZX109):基于肾小管上皮细胞外泌体调控的PPARγ信号通路探讨补阳还五汤干预肾间质纤维化的作用机制,负责人:杨康. （2022JDZX109）
