世界科学技术-中医药现代化2025，Vol.27Issue(2)：346-354,9.DOI:10.11842/wst.20240414001
基于可视化分析方法探究动物实验中针刺干预阿尔茨海默病的作用机制研究现状
Exploring the Current Status of Research on the Mechanism of Acupuncture Intervention in Alzheimer's Disease in Animal Experiments Using Visual Analysis Methods
摘要
Abstract
Objective In this paper,CiteSpace(V6.3.R1)was used to sort out and summarize the experimental study on the mechanism and development trend of acupuncture intervention in Alzheimer's disease(AD),so as to provide basis and suggestions for subsequent research.Methods Relevant literatures on the mechanism of acupuncture intervention in AD were retrieved from CNKI database from March 1997 to March 2024.CiteSpace(V6.3.R1)software was used to visually display keywords,draw corresponding maps,and discuss the hot spots of acupuncture intervention mechanism in AD.Results After screening,a total of 397 articles were included in this study.The mechanism of acupuncture intervention in AD mainly focuses on the regulation of synaptic plasticity,regulation of neurotransmitter release,regulation of neuroinflammation,regulation of apoptosis,influence on mitochondrial autophagy,anti-oxidative stress and so on.Conclusion Acupuncture intervention in AD has developed rapidly,involving Notch1/Hes signaling pathway,Shh signaling pathway,NF-κB signaling pathway,PI3K/Akt signaling pathway and other signaling pathways.The research heat of TCM acupuncture intervention in AD continues to rise,and various research teams have harvested rich research results,diversified research hotspots,and in-depth exploration of acupuncture treatment of AD has rich clinical value.关键词
机制/针刺/阿尔茨海默病/实验研究/可视化Key words
Mechanism/Acupuncture/Alzheimer's disease/Experimental research/Visualization分类
医药卫生引用本文复制引用
左吉恒,杨璇,李冬华,汪子栋,李志刚,田会玲..基于可视化分析方法探究动物实验中针刺干预阿尔茨海默病的作用机制研究现状[J].世界科学技术-中医药现代化,2025,27(2):346-354,9.基金项目
北京中医药大学揭榜挂帅项目(2022-JYB-JBZR-024):穴位敏化的物质基础与成像研究,负责人:李志刚 （2022-JYB-JBZR-024）
国家自然科学基金面上项目(82274654):中性粒细胞黏附与内皮修复途径探讨"通督启神"针法干预AD的血脑屏障保护机制研究,负责人:李志刚 （82274654）
北京市教育委员会科技计划一般项目(KM202410025020):基于星形胶质细胞清除DNs探讨针刺改善AD小鼠认知水平的机制,负责人:田会玲. （KM202410025020）
