生命科学仪器2025，Vol.23Issue(1)：116-117,120,3.DOI:10.11967/2025230240
TP53/RB1突变型肺癌及其组织学转化的研究进展
The Research Progress of TP53/RB1 Mutated Lung Cancer And Its Histological Transformation
安婧 1马晓梅1
作者信息
- 1. 新疆医科大学附属肿瘤医院,新疆乌鲁木齐 830054
- 折叠
摘要
Abstract
Histological transformation of small cell lung cancer(SCLC)is an uncommon but important drug resist-ance mechanism in the treatment of non-small cell lung cancer(NSCLC)with tyrosine kinase inhibitor(TKI).The prognosis of patients with transformation is generally poor,and its pathogenesis and coping therapy are difficult problems in clinical research at present.The change of TP53/RB1 pathway is considered as an important condition for transformation.In this paper,the research status of TP53/RB1 in transformation in recent years is reviewed.关键词
TP53/RB1/肺癌/组织学转化Key words
TP53/RB1/Lung cancer/Histological transformation分类
医药卫生引用本文复制引用
安婧,马晓梅..TP53/RB1突变型肺癌及其组织学转化的研究进展[J].生命科学仪器,2025,23(1):116-117,120,3.
