山西医科大学学报2025，Vol.56Issue(2)：121-126,6.DOI:10.13753/j.issn.1007-6611.2025.02.002
类风湿关节炎与男性生殖器癌发病风险的关联性:孟德尔随机化分析
Mendelian randomization analysis of relationship between rheumatoid arthritis and male genital cancer
摘要
Abstract
Objective To investigate the relationship between rheumatoid arthritis(RA)and male genital cancer using Mendelian ran-domization.Methods Based on the data of single-nucleotide polymorphism(SNP)from genome-wide association studies(GWAS),the causal relationship between RA and male genital cancer was investigated by inverse variance weighted(IVW)method,supple-mented with simple model method,weighted median method,weighted model methods,and MR-Egger regression method.The accu-racy of the results was verified through sensitivity tests including Cochran's Q test,MR-Egger intercept assessment and leave-one-out analysis.Results There was a causal relationship between RA and the incidence of male genital cancer.IVW results revealed a posi-tive correlation between RA and the risk of male genital cancer(ID:ebi-a-GCST90018910,OR=1.001,95%CI:1.001-1.002,P<0.05;ID:ebi-a-GCST90038685,OR=1.221,95%CI:1.030-1.446,P<0.05).Sensitivity analysis did not reveal heterogeneity or hori-zontal multicollinearity,and the leave-one-out test indicated stable results.Conclusion RA may increase the risk of male genital cancer.关键词
类风湿关节炎/阴茎癌/睾丸癌/孟德尔随机化/单核苷酸多样性/炎症因子/因果关系Key words
rheumatoid arthritis/penile cancer/testicular cancer/Mendelian randomization/single-nucleotide polymorphism/inflammatory factors/causal relationship分类
医药卫生引用本文复制引用
王盛越,孙自学..类风湿关节炎与男性生殖器癌发病风险的关联性:孟德尔随机化分析[J].山西医科大学学报,2025,56(2):121-126,6.基金项目
国家自然科学基金面上项目(82274536) （82274536）
国家中医药管理局高水平中医药重点学科--中医男科学科建设项目(ZYYZDXK-2023134) （ZYYZDXK-2023134）
河南省生殖障碍疾病中医药防治工程研究中心(2023HNGCZX09) （2023HNGCZX09）
河南省防治生殖障碍疾病中医药重点实验室项目(2021ZDSYS10) （2021ZDSYS10）
