类风湿关节炎与男性生殖器癌发病风险的关联性:孟德尔随机化分析OA

Objective To investigate the relationship between rheumatoid arthritis(RA)and male genital cancer using Mendelian ran-domization.Methods Based on the data of single-nucleotide polymorphism(SNP)from genome-wide association studies(GWAS),the causal relationship between RA and male genital cancer was investigated by inverse variance weighted(IVW)method,supple-mented with simple model method,weighted median method,weighted model methods,and MR-Egger regression method.The accu-racy of the results was verified through sensitivity tests including Cochran's Q test,MR-Egger intercept assessment and leave-one-out analysis.Results There was a causal relationship between RA and the incidence of male genital cancer.IVW results revealed a posi-tive correlation between RA and the risk of male genital cancer(ID:ebi-a-GCST90018910,OR=1.001,95%CI:1.001-1.002,P<0.05;ID:ebi-a-GCST90038685,OR=1.221,95%CI:1.030-1.446,P<0.05).Sensitivity analysis did not reveal heterogeneity or hori-zontal multicollinearity,and the leave-one-out test indicated stable results.Conclusion RA may increase the risk of male genital cancer.