实用休克杂志（中英文）2024，Vol.8Issue(5)：273-276,4.
儿童百日咳鲍特菌感染后气道上皮IFN-λ1mRNA表达水平的研究
Study on the expression level of IFN-λ1mRNA in airway epithelium of children infected with Bordetella pertussis
摘要
Abstract
Objective To observe and analyze the expression of Interferon-λ1(IFN-λ1)mRNA in respiratory epithelial cells of children infected with Bordetella pertussis,and to explore the role of Interferon-λ1 in pertussis mucosal immune response.Methods Patients who visited our hospital from September 2019 to February 2020 and were highly considered to have pertussis infection or spasmodic cough were selected as the research subjects.A total of 206 specimens were collected as the experi-mental group.Additionally,71 children undergoing physical examinations at our from April 2020 to March 2021 were collected as the control group.Perform IFN-λ1mRNA detection on specimens from each group,and statistically analyze the difference in IFN-λ1mRNA expression in airway epithelium between the experimental group and the control group.Results The expression level of IFN-λ1mRNA in the airway epithelium of children with pertussis infection was significantly lower than that of the healthy control group(P＜0.05).Conclusions IFN-λ1 may be involved in the mucosal im-mune response after pertussis infection.关键词
百日咳/儿童/λ1干扰素/黏膜免疫反应Key words
Pertussis/Children/IFN-λ1/Mucosal immune response引用本文复制引用
陶美婷,钟礼立,刘思兰,曾丹,刘丹,彭力..儿童百日咳鲍特菌感染后气道上皮IFN-λ1mRNA表达水平的研究[J].实用休克杂志（中英文）,2024,8(5):273-276,4.基金项目
湖南省自然科学基金(项目编号:2024JJ9141、2022JJ70014) （项目编号:2024JJ9141、2022JJ70014）
