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心肺复苏后昏迷患者神经功能预后生物标志物的研究进展

李星明 孙广琦 郑雯 张正国 徐峰 陈玉国

实用休克杂志(中英文)2024,Vol.8Issue(5):290-298,9.
实用休克杂志(中英文)2024,Vol.8Issue(5):290-298,9.

心肺复苏后昏迷患者神经功能预后生物标志物的研究进展

Research progress of biomarkers of neurological function prognosis in coma patients after cardiopulmo-nary resuscitation

李星明 1孙广琦 1郑雯 1张正国 2徐峰 1陈玉国1

作者信息

  • 1. 山东大学齐鲁医院急诊科||山东省急危重症临床医学研究中心||教育部急危重症医药基础研究创新中心||国家药监局创新药物临床研究与评价重点实验室
  • 2. 山东大学齐鲁医院
  • 折叠

摘要

Abstract

Patients with cardiac arrest may still be in a coma after recovering from cardiopulmo-nary resuscitation.Compared with clinical examination,neuroelectrophysiology and imaging examina-tion,serum biomarkers are widely used to predict the prognosis of neurological function in these pa-tients because they can better balance the specificity and sensitivity of prediction,are easy to obtain,and are less affected by calming drugs.However,the timing and threshold of biomarkers that have been used in the clinic are still controversial,and new biomarkers continue to show the effectiveness of the prognosis of neurological function.Therefore,this paper will review the biomarkers related to neurological function prognosis of coma patients after cardiopulmonary resuscitation,in order to pro-vide a theoretical basis for a comprehensive understanding of the research status in this field and to find possible breakthrough directions.

关键词

心脏骤停/心肺复苏/神经功能预后/生物标志物

Key words

Cardiac arrest/Cardiopulmonary resuscitation/Neurological function prognosis/Biomarkers

引用本文复制引用

李星明,孙广琦,郑雯,张正国,徐峰,陈玉国..心肺复苏后昏迷患者神经功能预后生物标志物的研究进展[J].实用休克杂志(中英文),2024,8(5):290-298,9.

基金项目

国家自然科学基金(项目编号:82325031) (项目编号:82325031)

四大慢病重大专项(项目编号:2023ZD0505504、2023ZD0505500) (项目编号:2023ZD0505504、2023ZD0505500)

山东省重点研发计划(项目编号:2022ZLGX03) (项目编号:2022ZLGX03)

实用休克杂志(中英文)

2096-4544

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