实用医学杂志2025，Vol.41Issue(5)：621-627,7.DOI:10.3969/j.issn.1006-5725.2025.05.001
自然杀伤细胞疗法的机遇与挑战
Opportunities and challenges of NK cell therapy
摘要
Abstract
Natural killer(NK)cells are essential components of the innate immune system,characterized by their ability to identify and eliminate abnormal cells through receptors that operate independently of major histo-compatibility complex(MHC)restriction.As a result,NK cells play a critical role in anti-tumor,antiviral,and immune regulatory responses.Chimeric antigen receptor NK cell therapy(CAR-NK)enhances the targeting speci-ficity and functional activity of NK cells,thereby augmenting their cytotoxic potential and opening new avenues for cancer treatment.To date,numerous clinical trials have evaluated NK cell therapy for anti-tumor,antiviral,and autoimmune diseases.This article summarizes the current research status of NK cell therapy in clinical applica-tions,highlighting its promising efficacy and safety as an innovative immunotherapy.Despite challenges such as limited cell persistence and tumor microenvironment suppression,the prospects for further development in this field remain promising.关键词
自然杀伤细胞/细胞治疗/嵌合抗原受体NK细胞免疫疗法Key words
natural killer cells/cell therapy/chimeric antigen receptor NK cells分类
医药卫生引用本文复制引用
丁亦扬,赵翔宇..自然杀伤细胞疗法的机遇与挑战[J].实用医学杂志,2025,41(5):621-627,7.基金项目
国家自然科学基金项目(编号:82070184,82350105,82270228) （编号:82070184,82350105,82270228）
四大慢病重大专项(编号:2023ZD0501200) （编号:2023ZD0501200）
科技部雄安新区科技创新专项(编号:2023XACX0004) （编号:2023XACX0004）
北京高等学校卓越青年科学家计划资助项目(编号:JWZQ20240101001) （编号:JWZQ20240101001）
北京市自然科学基金项目(编号:Z240019) （编号:Z240019）
