实用医学杂志2025，Vol.41Issue(5)：634-640,7.DOI:10.3969/j.issn.1006-5725.2025.05.003
异基因造血干细胞移植后急性移植物抗宿主病的治疗新靶点
New targets for the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
摘要
Abstract
Allogeneic haematopoietic stem cell transplantation(allo-HSCT)is the most effective curative treatment for hematologic malignancies.Its efficacy hinges on eliminating primary hematological disorders and restoring bone marrow hematopoiesis during conditioning,as well as leveraging the graft-versus-leukemia(GVL)effect.However,acute graft-versus-host disease(aGVHD)remains a significant complication following allo-HSCT,substantially affecting patient survival and quality of life.Current preclinical studies focus on strategies to mitigate aGVHD while preserving adequate GVL effects to improve transplant outcomes.This review summarizes recent preclinical research findings in this field,emphasizing the regulatory roles and specific molecular mechanisms of T cells,antigen-presenting cells,myeloid-derived suppressor cells,and mesenchymal stem cells in aGVHD.It further highlights the latest therapeutic strategies for aGVHD from preclinical studies,aiming to provide valuable insights for researchers and clinicians to develop more effective therapeutic targets and strategies.关键词
造血干细胞移植/急性移植物抗宿主病/移植物抗白血病效应/T细胞/抗原提呈细胞/髓源性抑制细胞/间充质干细胞/信号通路Key words
haematopoietic stem cell transplantation/acute graft-versus-host disease/graft-versus-leukemia effect/T cells/antigen-presenting cells/myeloid-derived suppressor cells/mesenchymal stem cells/signaling pathways分类
临床医学引用本文复制引用
段昊良,茹煜华,陈佳..异基因造血干细胞移植后急性移植物抗宿主病的治疗新靶点[J].实用医学杂志,2025,41(5):634-640,7.基金项目
国家自然科学基金面上项目(编号:82370215) （编号:82370215）
江苏省血液病医学创新中心(编号:CXZX202201) （编号:CXZX202201）
苏州市医学应用基础研究项目(编号:SKY2023047) （编号:SKY2023047）
