实用医学杂志2025，Vol.41Issue(5)：641-647,7.DOI:10.3969/j.issn.1006-5725.2025.05.004
异基因造血干细胞移植后的免疫相关研究进展
Advances in immunological research on hematopoietic stem cell transplantation
摘要
Abstract
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is a therapeutic approach that restores hematopoietic and immune functions in recipients through the infusion of allogeneic hematopoietic stem cells.It has evolved into an effective form of adoptive cellular immunotherapy,offering curative potential for vari-ous diseases,including malignant hematologic disorders,hematopoietic failure syndromes,congenital immunodefi-ciencies,and genetic metabolic disorders.Immunology plays a pivotal role in allo-HSCT,as post-transplant immu-nobiology is uniquely characterized by the potential for immune recognition and attack between donor and host cells.This review elucidates the distinctive features of immune reconstitution following allo-HSCT,examines the immunological underpinnings of graft-versus-host disease(GVHD)and the graft-versus-leukemia(GVL)effect,and evaluates how novel therapeutic strategies modulate these immune responses to improve the management of transplant-related complications and enhance patient outcomes.Additionally,the review addresses the challenges in balancing GVHD and GVL effects and outlines potential directions for future research.关键词
异基因造血干细胞移植/免疫机制/恶性血液病Key words
hematopoietic stem cell transplantation/immunological mechanisms/malignant hemato-logical diseases分类
基础医学引用本文复制引用
陈星驰,朱小玉..异基因造血干细胞移植后的免疫相关研究进展[J].实用医学杂志,2025,41(5):641-647,7.基金项目
国家自然科学基金面上项目(编号:82270223) （编号:82270223）
