实用医学杂志2025，Vol.41Issue(5)：648-656,9.DOI:10.3969/j.issn.1006-5725.2025.05.005
昼夜节律基因调控消化系统肿瘤及中药干预作用的研究进展
Research progress on circadian rhythm genes regulating digestive system tumors and the intervention of traditional Chinese medicine
摘要
Abstract
Circadian rhythms,a result of the long-term evolution of organisms adapting to the Earth′s environment,play a crucial regulatory role in biological activities.Disruptions in circadian rhythms have been iden-tified as potential carcinogenic risk factors,closely linked to the pathological states of digestive system diseases,and significantly contribute to the occurrence and progression of digestive system tumors.These rhythms not only influence the regulation of cell cycles,proliferation,and apoptosis of tumor cells but also profoundly affect their migratory abilities,immune functions,and drug resistance.This article focuses on the specific regulatory mechanisms of circadian rhythm genes in relation to digestive system tumors and comprehensively summarizes research findings on the anti-tumor effects of traditional Chinese medicine targeting these circadian clock genes.The aim is to provide new avenues for target selection and prognostic evaluation in the treatment of digestive system tumors.关键词
昼夜节律/生物钟基因/消化系统肿瘤/中药/机制Key words
circadian rhythm/circadian clock genes/digestive system tumors/traditional Chinese medicine/mechanism分类
医药卫生引用本文复制引用
孙硕,张文洁,赵益,孙有智..昼夜节律基因调控消化系统肿瘤及中药干预作用的研究进展[J].实用医学杂志,2025,41(5):648-656,9.基金项目
国家自然科学基金项目(编号:82360961,82060868) （编号:82360961,82060868）
江西省中医药骨干人才培养项目(编号:赣中医药科教字[2021]4号) （编号:赣中医药科教字[2021]4号）
江西省教育厅科学技术研究项目(编号:GJJ2200907) （编号:GJJ2200907）
江西中医药大学校级科技创新团队发展计划(编号:CXTD22007,CXTD22008) （编号:CXTD22007,CXTD22008）
