实用医学杂志2025，Vol.41Issue(5)：699-703,5.DOI:10.3969/j.issn.1006-5725.2025.05.012
老年急性前壁心肌梗死患者急诊经皮冠状动脉介入术前主动脉内球囊反搏联合术后重组人脑利钠肽对心室重构的影响
Effect of intra-aortic balloon counterpulsation combined with rhBNP on ventricular remodeling in elderly patients with acute anterior myocardial infarction before emergency PCI
摘要
Abstract
Objective The effect of intra-aortic balloon counterpulsation combined with recombinant human brain natriuretic peptide(rhBNP)treatment on ventricular remodeling after percutaneous coronary intervention(PCI)in elderly patients with acute anterior wall myocardial infarction.Methods A retrospective analysis was con-ducted on 66 elderly patients with acute anterior myocardial infarction who underwent emergency PCI in our hospital from January 2018 to June 2023.They were divided into a control group(n=32)who underwent PCI+rhBNP,and a study group(n=32)who underwent PCI+rhBNP+intra-aortic balloon counterpulsation.Blood pressure,lactic acid level,mechanical complications,ventricular remodeling,inflammatory factors,myocardial enzymology,ox-LDL level were detected and compared between the two groups.Results Before treatment,Lactic acid,diastolic blood pressure,systolic blood pressure,left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular posterior wall thickness(LVPWT),left ventricular remodeling index(LVRI),left ventricular ejection fraction(LVEF),homocysteine(Hcy),interleukin-6(IL-6)and myocardial troponin were compared between the two groups.Myocardial troponin T(cTnT),lactate dehydrogenase(LDH),creatine kinase isoenzyme(CK-MB),oxidized low density lipoprotein(ox-LDL)levels(P>0.05);At 3 months follow-up after discharge,the levels of lactic acid,LVESD,LVEDD,LVPWT,LVRI,Hcy,IL-6,cTnT,LDH,CK-MB and ox-LDL were decreased,and the levels were lower in the study group,and the levels of diastolic blood pressure,systolic blood pressure and LVEF were increased,and the levels were higher in the study group(P<0.05).The pro-portion of mechanical complications between the two groups before and after treatment were compared(P>0.05).Conclusion In elderly patients with acute anterior myocardial infarction after emergency PCI,intra-aortic balloon counterpulsation combined with rhBNP could alleviate ventricular remodeling,myocardial injury,reduce inflamma-tory injury,improve oxidative stress response,and regulate tissue perfusion.关键词
主动脉内球囊反搏/重组人脑利钠肽/急性前壁心肌梗死/经皮冠状动脉介入术/心室重构Key words
intra-aortic balloon counterpulsation/recombinant human brain natriuretic peptide/acute anterior myocardial infarction/percutaneous coronary intervention/ventricular remodeling分类
医药卫生引用本文复制引用
李圣博,冯玲,陈贝贝,姚芳,邢永生,刘艳宾..老年急性前壁心肌梗死患者急诊经皮冠状动脉介入术前主动脉内球囊反搏联合术后重组人脑利钠肽对心室重构的影响[J].实用医学杂志,2025,41(5):699-703,5.基金项目
河南省科技攻关(指导立项)(编号:232102310257) （指导立项）
