计算机技术与发展2025，Vol.35Issue(3)：156-164,9.DOI:10.20165/j.cnki.ISSN1673-629X.2024.0333
基于层级配准的冠脉树图谱构建及形态分析
Construction and Morphology Analysis of Coronary Artery Tree Atlas Based on Hierarchical Registration
摘要
Abstract
The tree-like structure characteristics of coronary arteries can assist doctors in assessing and diagnosing the state of coronary diseases more rapidly and accurately.The coronary tree atlas,as a morphology template,highlights individual morphological differences,aiding doctors in evaluating coronary health.To address the issues of significant morphological differences between individuals,and similar vascular branch morphologies within the same individual during the atlas construction,a framework for constructing coronary artery tree atlas based on hierarchical registration is proposed.The atlas construction framework employs a hierarchical registration strategy,progressing from coarse to fine.Given a coronary tree template,individual coronary artery tree is first aligned to the template using rigid registration,reducing the influence of spatial distance on the similarity measurement of vascular branches.Then,partition-based non-rigid registration method is applied to vascular branches with similarity to achieve localization and repair of missing vascular branches,constructing a coronary artery tree atlas with rich morphology.Moreover,three morphological analysis indicators:matching branch proportion,matching branch similarity,and registration success rate are proposed to compare the morphological differences between individual coronary arteries and the atlas for the morphological analysis of individual coronary trees and the screening of diseased coronary arteries.Experimental results show that the morphological analysis indicators achieve 90%accuracy,precision,sensitivity,specificity,and F1-score in diagnostic screening.关键词
冠脉疾病计算机辅助诊断/图谱构建/形态分析/刚性配准/层级配准Key words
coronary artery disease computer-aided diagnosis/atlas construction/morphology analysis/rigid registration/hierarchical reg-istration分类
计算机与自动化引用本文复制引用
赵妍,张晓,冯筠..基于层级配准的冠脉树图谱构建及形态分析[J].计算机技术与发展,2025,35(3):156-164,9.基金项目
国家自然科学基金项目(62073260) （62073260）
