湖北科技学院学报（医学版）2025，Vol.39Issue(2)：121-125,5.DOI:10.16751/j.cnki.2095-4646.2024071906
多西环素联合甲泼尼龙对儿童重症支原体肺炎症状转归及血清炎症相关指标的影响
Effect of Doxycycline Combined with Methylprednisolone on the Symptom Progression and Serum Inflammation Related Indicators in Children with Severe Mycoplasma Pneumonia
摘要
Abstract
Objective To investigate the effects of combined treatment with doxycycline and methylprednisolone on symp-tom progression and serum inflammation related indicators in children with severe mycoplasma pneumonia.Methods 86 children with severe mycoplasma pneumonia who received treatment in the pediatrics department of the First Affiliated Hospital of Bengbu Medical University from March 2023 to April 2024 were randomly divided into an observation group and a control group,with 43 cases in each group,using a random number table method.On the basis of conventional treatment,the observation group was treated with doxycycline combined with methylprednisolone,while the control group was treated with azithromycin combined with methyl-prednisolone for 7 consecutive days.The clinical efficacy,symptom improvement time,changes in serum inflammation related indi-cators[lactate dehydrogenase(LDH),interleukin-6(IL-6),C-reactive protein(CRP)]before and after treatment,lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow rate(PEF)],and adverse reac-tions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the improvement time of each symptom was shorter than that of the control group,with significant differences be-tween the two groups(P＜0.05);After treatment,the LDH,IL-6,and CRP levels in the observation group were lower than those in the control group,while the FEV1,FVC,and PEF levels were higher than those in the control group,with significant differences be-tween the two groups(P＜0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of doxycycline and methylprednisolone is effective in treating severe mycoplasma pneu-monia in children.It can shorten the time for symptom improvement,reduce inflammation levels,improve lung function,and is rela-tively safe for short-term use.关键词
支原体肺炎/重症/多西环素/甲泼尼龙/阿奇霉素Key words
Mycoplasma pneumonia/Severe illness/Doxycycline/Methylprednisolone/Azithromycin分类
药学引用本文复制引用
胡庆岩,夏群,赵冰..多西环素联合甲泼尼龙对儿童重症支原体肺炎症状转归及血清炎症相关指标的影响[J].湖北科技学院学报（医学版）,2025,39(2):121-125,5.基金项目
蚌埠医科大学自然科学基金重点项目(2023byzd085) （2023byzd085）
