摘要
Abstract
Objective To investigate the efficacy of alprostadil combined with Shenmai injection in the treatment of acute severe pancreatitis(SAP)and its effect on serum C-reactive protein(CRP)and procalcitonin(PCT).Methods 122 patients with SAP admitted to the hospital were enrolled and divided into control group and observation group by random number table method with 61 patients in each group.The control group was treated with Shenmai injection,and the observation group was treated with al-prostadil based on the treatment of the control group.The clinical effects,recovery time of clinical symptoms,serum biochemical in-dicators,and the incidence of adverse reactions were compared between the two groups.Results Compared with the control group,the total effective rate of treatment in the observation group was higher(90.16％vs 75.41％)(P＜0.05),the recovery time of abdominal pain,bloating,nausea and vomiting and gastrointestinal function in the observation group was shorter(P＜0.05).After treatment,the levels of amylase(AMY),lactate dehydrogenase(LDH),lipase(LPS)and creatinine(Cr)were decreased,and the levels of albumin(ALB)and prealbumin(PA)were increased in the two groups.Compared with the control group,the levels of AMY,LDH,LPS and Cr in the observation group were lower,and the levels of ALB and PA in the observation group were higher(P＜0.05).After treatment,the levels of CRP,PCT and IL-6 in the observation group were significantly lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group(9.84％)and the control group(8.20％)were nosignificantly difference(P＞0.05).Conclusion Alprostadil can help strengthen the clinical efficacy of Shenmai injection in acute severe pancreatitis,improve the clinical symptoms and serum biochemical improvement effect,and has good safety and is worthy of clinical promotion.关键词
急性重症胰腺炎/前列地尔/参麦注射液/C反应蛋白/降钙素原Key words
Severe acute pancreatitis/Alprostadil/Shenmai injection/C-reactive protein/Procalcitonin分类
临床医学
