摘要
Abstract
Objective To analyze the effects of Yiqi Hewei Capsule combined with conventional western medicine on gas-trointestinal function and inflammatory mediators in patients with chronic atrophic gastritis(CAG).Methods A retrospective anal-ysis was performed on the data of 122 patients with CAG in our hospital from February 2021 to February 2023,and they were divid-ed into a control group(treated with omeprazole)andan observation group(treated with Yiqi Hewei Capsule+omeprazole)ac-cording to the principle of 1∶1 matching principle,with 61 cases in each group.The clinical efficacy,TCM syndrome scores,gastric mucosal pathological scores,gastrointestinal function indexes[motilin(MTL),epidermal growth factor(EGF),gastrin(GAS)],and serum inflammatory mediators[interleukin(IL-6,IL-33),tumor necrosis cytokine-α(TNF-α)]were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 90.16％(55/61),which was higher than that of the control group(75.41％(46/61)(P＜0.05).The atrophy,chronic inflammation,activity scores,and the main and secondary symptoms of TCM syndrome in the observation group were lower than those in the control group(P＜0.05).Compared with before treatment,GAS decreased in both groups,while MTL and EGF increased,and the levels in the observation group were more significant(P＜0.05).After treatment,the decreases in IL-6,IL-33,and TNF-α in the observation group were greater than those in the control group(P＜0.05).Conclusion The treatment of CAG patients with Yiqi Hewei Capsule combined with omeprazole enteric-coated capsule has a significant effect,which can reduce symptoms,inhibit inflammatory response,and im-prove gastrointestinal function.关键词
慢性萎缩性胃炎/益气和胃胶囊/奥美拉唑肠溶胶囊/胃肠功能/白介素-33Key words
Chronic atrophic gastritis/Yiqi Hewei Capsule/Omeprazole enteric-coated capsules/Gastrointestinal function/Interleukin-33分类
医药卫生
