湖北科技学院学报（医学版）2025，Vol.39Issue(2)：142-146,5.DOI:10.16751/j.cnki.2095-4646.2024102315
高血压与肾结石及输尿管结石风险之间的因果关系:一项孟德尔随机化研究
Causality Between Hypertension and The Risk of Kidney and Ureteral Calculus:A Mendelian Randomization Study
摘要
Abstract
Objective Mendelian randomization(MR)was used to investigate the causal relationship between hypertension and kidney and ureteral calculus.Methods All research data were collected from the IEU Open GWAS Project database.The hy-pertension dataset included 55 955 patients and 162 837 controls,including 16 380 466 single nucleotide polymorphisms(SNP)for association analyses.The dataset for kidney and ureteral calculus included 2427 patients and 334 772 controls,including 10 894596 SNPs for association analyses.The instrumental variable SNP was screened,and the results of inverse variance weighted(IVW)method were used as the main index of the effect.The results of MR-Egger regression,weighted median method,and mode-based weighted estimation were used as references.The sensitivity was tested by leave-one-out method,the heterogeneity was determined by Cochran's Q test by IVW method and MR-Egger method,and the horizontal pleiotropy was tested by pleiotropy function.Results After screening,a total of 60 instrumental variable SNPs were selected.The results of heterogeneity test showed that there was a certain degree of heterogeneity among SNPs(P＜0.05 for both IVW method and MR-Egger method).Therefore,the results of ran-dom effects model were used for effect evaluation.IVW and weighted median methods showed evidence to support a causal relation-ship between hypertension and kidney and ureteral calculus.MR-pleiotropy function test showed that horizontal pleiotropy was un-likely to affect the results(intercept=-6.5e-05;P=0.643).The leave-one-out method showed that no SNPs were present that significantly affected the results.At the same time,the odds ratio and 95％confidence Interval of IVW method and weighted medi-an method were both greater than 1,indicating that hypertension was positively correlated with the increased risk of kidney and ure-teral calculus.Conclusion MR analysis provides strong evidence that hypertension may have a causal relationship with kidney and ureteral calculus,and that hypertension promotes the occurrence and progression of kidney and ureteral calculus.关键词
高血压/肾结石/输尿管结石/孟德尔随机化Key words
Hypertension/Calculus of kidney/Calculus of ureteral/Mendelian randomization分类
医药卫生引用本文复制引用
潘照文,涂毅威,付梓祥,陈红,汤行,余薇,夏燕..高血压与肾结石及输尿管结石风险之间的因果关系:一项孟德尔随机化研究[J].湖北科技学院学报（医学版）,2025,39(2):142-146,5.基金项目
湖北科技学院校级横向项目(2024HX086) （2024HX086）
