眼科学报2025，Vol.40Issue(2)：85-95,11.DOI:10.12419/25021301
眼底疾病临床创新研究模式:六要素,三个一
Clinical innovation research model for fundus diseases:6 elements,3 ones
文峰 1张雄泽 1李妙玲 1甘雨虹 1苏永悦1
作者信息
- 1. 中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060
- 折叠
摘要
Abstract
The"6 Elements,3 Ones"constitutes a methodological framework for conducting innovative clinical research of ocular fundus diseases in foundational fundus imaging interpretation.This model emphasizes:1)identifying a single abnormal case during routine fundus evaluation;2)systematically expanding this observation into a case series through case accumulation,feature extraction,literature review,and comparative analysis;and 3)ultimately proposing or refining novel disease entities or manifestations through critical thinking and innovation.Over the past two decades,guided by this paradigm,our research team has achieved several original breakthroughs in fundus imaging studies,including:establishing polypoidal choroidal vasculopathy as the predominant subtype of neovascular age-related macular degeneration in Chinese populations;proposing an international staging system and novel subtypes for punctate inner choroidopathy;elucidating the pathogenesis of retentional retinal pigment epithelial detachment through the sign of age-related scattered hypofluorescent spots on late-phase indocyanine green angiography;identifying acute macular neuroretinopathy as the primary cause of vision loss in dengue fever patients;and precisely localizing lesion in the world's largest case series of persistent placoid maculopathy.The"6 Elements"framework standardizes fundus disease research protocols,emphasizing methodological rigor and progressive investigation while generating multiple research trajectories through iterative cycles,thereby expanding both the depth and breadth of scientific inquiry.The"3 Ones"pathway embodies hierarchical research progression-transitioning from individual phenomena(point observations)to population-level patterns(linear correlations),ultimately constructing a multidimensional disease cognition network(planar integration).This approach guides investigations ranging from signs of common disease to rare disorders and novel disease entities,accelerating the refinement of disease taxonomies.By adhering to the"6 Elements"as the structural framework and implementing the"3 Ones"as the strategic pathway,we will continue to advance innovation and achieve breakthroughs in clinical fundus disease researches.关键词
眼底疾病/眼底影像/创新研究/工作模式Key words
ocular fundus disease/fundus imaging/innovative research/working model分类
临床医学引用本文复制引用
文峰,张雄泽,李妙玲,甘雨虹,苏永悦..眼底疾病临床创新研究模式:六要素,三个一[J].眼科学报,2025,40(2):85-95,11.
