经颅多普勒超声持续监测辅助阿替普酶静脉溶栓治疗急性缺血性脑卒中患者的临床效果观察OA

Objective To observe the clinical effect of transcranial doppler ultrasound(TCD)continuous monitoring assisted alteplase intravenous thrombolysis in the treatment of patients with acute ischemic stroke(AIS).Methods According to the random number table method,82 patients with AIS admitted to Nanyang Central Hospital from May 2023 to May 2024 were divided into the reference group(41 cases)and the study group(41 cases).The reference group was treated with conventional alteplase intravenous thrombolysis,and the study group was treated with TCD continuous monitoring assisted alteplase intravenous thrombolysis.The vascular recanalization,neurological function,self-care ability,prognosis,levels of cerebral hemodynamic index after treatment and adverse reactions were compared between the two groups.Results After treatment,the TIBI grading in the study group was better than that in the reference group,the NIHSS score and MRS score were lower than those in the reference group,the BI score was higher than that in the reference group,and the Vm of BA,ACA and MCA was higher than that in the reference group(P＜0.05).The total incidence of adverse reactions was 4.88％in the study group and 9.76％in the reference group,and the difference was not significant(P＞0.05).Conclusions TCD continuous monitoring assisted alteplase intravenous thrombolysis can improve the vascular recanalization rate of AIS patients,improve the cerebral hemodynamics and neurological function of patients,and improve the self-care ability of patients,improve the prognosis of patients,and do not significantly increase the risk of adverse reactions in patients.