医学信息2025，Vol.38Issue(4)：16-20,5.DOI:10.3969/j.issn.1006-1959.2025.04.003
基于孟德尔随机化方法研究睡眠时长与结直肠癌发病风险的因果关联
The Causal Association Between Sleep Duration and the Risk of Colorectal Cancer Based on Mendelian Randomization Method
王彧 1王奕潇 1杜美志 1孙枫雅 1戴琳娜 1刘芳睿 1韦远奇 2朱云1
作者信息
- 1. 天津医科大学公共卫生学院,天津 300070
- 2. 天津医科大学生物医学工程与技术学院,天津300070
- 折叠
摘要
Abstract
Objective To explore the association between sleep duration and the risk of colorectal cancer by two-sample Mendelian randomization design.Methods Genome-wide association study(GWAS)data related to sleep duration and the risk of colorectal cancer were screened and extracted from the IEU OpenGWAS project website database.The GWAS data of sleep duration were derived from the meta-analysis data of 460 099 European populations,including 9 851 867 single nucleotide polymorphism(SNP)loci.The GWAS data of colorectal cancer included 218792 European population meta-analysis data(3022 cases of colorectal cancer and 215 770 cases of control group),with a total of 16 380 466 SNP loci.Inverse variance weighting(IVW)was used to evaluate the relationship between different sleep durations predicted by genetics and the risk of colorectal cancer.Heterogeneity test and MR-Egger regression and one-by-one rejection experiments were used for sensitivity analysis to evaluate the pleiotropy of instrumental variables.Results The results of IVW method showed that sleep duration predicted by genetics was negatively correlated with the risk of colorectal cancer(OR=0.494,95%CI:0.264-0.924).MR-Egger regression suggested that the above causal associations were not affected by level pleiotropy.Conclusion Sleep duration is a protective factor for colorectal cancer.With the increase of sleep duration,the risk of colorectal cancer decreases.关键词
结直肠癌/睡眠时长/工具变量/因果关联/孟德尔随机化Key words
Colorectal cancer/Sleep duration/Instrumental variables/Causal relationship/Mendelian randomization分类
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王彧,王奕潇,杜美志,孙枫雅,戴琳娜,刘芳睿,韦远奇,朱云..基于孟德尔随机化方法研究睡眠时长与结直肠癌发病风险的因果关联[J].医学信息,2025,38(4):16-20,5.
