医学信息2025，Vol.38Issue(4)：29-36,8.DOI:10.3969/j.issn.1006-1959.2025.04.005
肝移植患者非计划性再入院发生率及影响因素的Meta分析
Meta-analysis of the Incidence and Influencing Factors of Unplanned Readmission in Patients Undergoing Liver Transplantation
摘要
Abstract
Objective To investigate the incidence and influencing factors of unplanned readmission in patients undergoing liver transplantation,and to provide evidence for early identification of readmission.Methods The relevant literatures published in PubMed,Web of Science,EMbase,The Cochrane Library,CNKI,Wanfang,Chinese Biomedical Literature Database and VIP Database were searched by computer.The retrieval time was from the establishment of the database to September 23,2023.Two researchers independently screened the literature,extracted the data,and evaluated the quality of bias risk of the literature.Meta-analysis was performed using Stata16 software.Results A total of 18 articles were included,and the overall quality of the literature was moderately high,with a total sample size of 45 320 cases.The incidence of unplanned readmission in patients with liver transplantation ranged from 10%to 64%,and the combined incidence was 38%(95%CI:0.34-0.43).Recipient age[OR=1.04,95%CI(1.02,1.07),P＜0.001],infection[OR=1.32,95%CI(0.87,2.01),P=0.003],diabetes mellitus[OR=2.54,95%CI(1.46,4.42),P=0.001],dialysis before transplantation[OR=1.83,95%CI(1.23,2.72),P=0.003],transplantation indication(etiology of liver disease)[OR=2.22,95%CI(1.68,2.92)].P＜0.001],organ donation type[OR=1.23,95%CI(1.01,1.50),P=0.036],postoperative complications[OR=1.34,95%CI(1.01,1.67),P=0.017]were risk factors for unplanned readmission in patients with liver transplantation.Male[OR=0.60,95%CI(0.44,0.83),P=0.002],use of reduced readmission regimen[OR=0.34,95%CI(0.23,0.53).P＜0.001]and discharge at weekends[OR=0.41,95%CI(0.25,0.66),P＜0.001]were protective factors for unplanned readmission in liver transplant patients.Conclusion Recipient age,infection,diabetes mellitus,dialysis before transplantation,transplantation indication(etiology of liver disease),type of organ donation,postoperative complications,male,use of reduced readmission program,and discharge at weekends are closely related to unplanned readmission of liver transplant patients.However,the literature included in this study is observational research,which has certain limitations,and more large-sample prospective cohort studies are needed to verify it.关键词
肝移植/非计划性再入院/影响因素/病例对照研究/队列研究/Meta分析Key words
Liver transplantation/Unplanned readmission/Influencing factors/Case-control study/Cohort study/Meta-analysis分类
医药卫生引用本文复制引用
贺田,沈鸣雁,方丹,贾欣宇,朱荣昌..肝移植患者非计划性再入院发生率及影响因素的Meta分析[J].医学信息,2025,38(4):29-36,8.基金项目
2024年度浙江省中医药科技计划(编号:2024ZL845) （编号:2024ZL845）
