摘要
Abstract
Objective To explore the predictive value of Krebs von den Lungen 6(KL-6)expression for the severity of community-acquired pneumonia(CAP).Methods Atotalof128adultpatientswith CAP(18patientsintheseveregroupand110patientsinthenon-severegroup)admitted to Jilin Provincial People's Hospital from March to April 2022 were selected.Another 128 healthy subjects(healthy control group)with matching gender and age were selected.The serum KL-6 levels of the three groups were detected and compared,and the relationship between serum KL-6 expression and the severity of CAP was analyzed.The receiver operating characteristic curve(ROC curve)was used to analyze the predictive value of serum KL-6 level for severe CAP.The sensitivity and specificity of serum KL-6 level as a differential diagnosis of severe and non-severe.Results The combined rate of severe group with liver disease,kidney disease,electrolyte disorder and cerebral infarction was higher than that of non-severe group,and the difference was statistically significant(P＜0.05),while there was no significant difference in the proportion of hypertension,diabetes,heart disease between the two groups(P＞0.05).The serum KL-6 level in severe group was higher than that in non-severe group and healthy control group,and the serum KL-6 level in non-severe group was higher than that in healthy control group(P＜0.05).ROC analysis showed that the area under the curve(AUC)was 92.20%,and the 95%CIwas(0.920,0.924),P=0.000.The optimal critical value was 439 U/ml,the sensitivity was 99.00%,and the specificity was 82.10%.Conclusion Serum KL-6 level is related to the severity of CAP,which has important reference value for early prediction of severe CAP and is worthy of clinical application.关键词
血清KL-6/社区获得性肺炎/重症Key words
Serum KL-6/Community-acquired pneumonia/Severe disease分类
临床医学
