医学信息2025，Vol.38Issue(4)：188-192,5.DOI:10.3969/j.issn.1006-1959.2025.04.036
肠道微生态在隐匿性肝性脑病中发病机制及治疗前景
The Pathogenesis and Treatment Prospect of Intestinal Microecology in Occult Hepatic Encephalopathy
摘要
Abstract
Covert hepatic encephalopathy(CHE)refers to a type of hepatic encephalopathy characterized by abnormalities discovered through neuropsychology and/or neurophysiology,but characterized by asymptomatic or only mild cognitive impairment,insomnia,sleep inversion,decreased computational and attention abilities.It is different from the typical symptoms of hepatic encephalopathy such as directional impairment and flapping tremors that appear in overt hepatic encephalopathy(OHE),and this type of hepatic encephalopathy is not easily detected.CHE is prone to develop into OHE,which reduces the survival rate of patients with liver cirrhosis,affects their fine motor skills,increases the risk of accidental injury,and increases the burden on families and society.The exact mechanism of covert hepatic encephalopathy is not yet clear.In recent years,research has found that changes in gut microbiota are closely related to the occurrence,development,and prognosis of hepatic encephalopathy.This article aims to systematically review the mechanism and treatment prospects of gut microbiota in Covert hepatic encephalopathy,and deeply explore the relationship between the two,providing theoretical basis for clinical prevention and treatment of CHE.关键词
肝性脑病/隐匿性肝性脑病/肠道微生态/益生元/益生菌Key words
Hepatic encephalopathy/Covert hepatic encephalopathy/Intestinal microecology/Prebiotics/Probiotics分类
医药卫生引用本文复制引用
韦影影,何宛蓉,梁运啸,凌铭霞..肠道微生态在隐匿性肝性脑病中发病机制及治疗前景[J].医学信息,2025,38(4):188-192,5.基金项目
1.广西卫健委科研课题(编号:Z20180684) （编号:Z20180684）
2.广西自然科学基金项目(编号:2020JJB140211) （编号:2020JJB140211）
