应用化学2025，Vol.42Issue(2)：168-181,14.DOI:10.19894/j.issn.1000-0518.240226
烟酰胺单核苷酸的抗衰老机制、应用及检测研究进展
Research Advances of Anti-Aging Mechanism,Application and Detection of Nicotinamide Mononucleotide
摘要
Abstract
Nicotinamide mononucleotide(NMN)is a naturally bioactive nucleotide and a synthetic precursor of nicotinamide adenine dinucleotide(NAD+/NADH),an essential coenzyme in the body.A comprehensive study of NMN can not only provide a method to delay aging,but also may bring new treatment opportunities for brain injury,cardiac injury,liver injury,diabetic nephropathy,sepsis,blindness,depression and so on.In this review,the anti-aging mechanism of NMN and its applications in anti-aging and medical treatment were introduced.The existing NMN detection methods at home and abroad were mainly discussed,including enzyme-coupled assay,electrochemical detection,quantitative nuclear magnetic resonance method,liquid chromatography method,liquid chromatography-mass spectrometry method and capillary electrophoresis method,and the linear range,detection limit and recovery rate of different methods were compared.Finally,the challenges and future directions of NMN research in terms of mechanism,practical application and detection analysis were discussed.关键词
烟酰胺单核苷酸/检测/应用/抗衰老Key words
Nicotinamide mononucleotide/Detection/Application/Anti-aging分类
化学引用本文复制引用
陈思维,王立世,江焕峰..烟酰胺单核苷酸的抗衰老机制、应用及检测研究进展[J].应用化学,2025,42(2):168-181,14.基金项目
国家重点研发计划项目(No.2022YFB4101800)、国家自然科学基金(No.22231002)和广东省基础与应用基础研究基金项目(No.2024B1515040027)资助 Supported by the National Key Research and Development Program of China(No.2022YFB4101800),the National Natural Science Foundation of China(No.22231002)and Guangdong Basic and Applied Basic Research Foundation(No.2024B1515040027) （No.2022YFB4101800）
