现代畜牧科技Issue(2)：7-9,3.DOI:10.19369/j.cnki.2095-9737.2025.02.003
基于网络药理学浅谈葛根芩连汤治疗羔羊腹泻的机理
A Brief Discussion on the Mechanism of Gegen Qinlian Decoction in Treating Lamb Diarrhea based on Network Pharmacology
摘要
Abstract
To analyze the efficacy of Gegen Qinlian Decoction in treating lamb diarrhea caused by atypical enteropathogenic Escherichia coli.Network pharmacology was used to analyze the diarrhea caused by Gegen Qinlian Decoction and atypical enteropathogenic Escherichia coli in lamb.As a result,Gegen Qinlian Decoction contains 53 active chemical ingredients and 233 drug targets.A total of 680 gene targets related to atypical enteropathogenic Escherichia coli acting on cows and calf diarrhea were collected.The drug active ingredient gene target network model of Gegen Qinlian Decoction for treating calf diarrhea caused by atypical intestinal pathogenic Escherichia coli revealed that PTGS2,AKT1,IL6,VEGFA,CASP8,CASP3,and TNF were key targets,while ketoxin,Epiberberine,Quercetin,β-sitosterol,Kaempferol,and Baicalin contained more related gene targets.The conclusion reveals the pharmacological mechanism of Gegen Qinlian Decoction in treating lamb diarrhea caused by atypical enteropathogenic Escherichia coli.关键词
葛根芩连汤/羔羊/腹泻/活性成分/靶基因Key words
Gegen Qinlian Decoction/lamb/diarrhea/active constituent/target gene分类
畜牧业引用本文复制引用
贾燕,李华坤,杨彬偲,陈兰..基于网络药理学浅谈葛根芩连汤治疗羔羊腹泻的机理[J].现代畜牧科技,2025,(2):7-9,3.基金项目
江苏现代农业(肉羊)产业技术体系项目(JATS[2023]053) （肉羊）
