中风与神经疾病杂志2025，Vol.42Issue(2)：104-108,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0021
西藏地区帕金森病患者焦虑抑郁状态及对生活质量的影响
Depression and anxiety and their influence on quality of life in patients with Parkinson disease in Tibet,China
摘要
Abstract
Objective To investigate the state of anxiety and depression in patients with Parkinson disease due to high-altitude exposure in Tibet,China and its impact on quality of life.Methods A total of 93 patients with Parkinson disease who attended Tibet Autonomous Region People's Hospital from February 2023 to November 2024 were enrolled,and basic informa-tion and assessment scales were collected.The Unified Parkinson's Disease Rating Scale Part Ⅲ(UPDRS-Ⅲ)and Hoehn-Yahr(H-Y)stage were used to evaluate disease severity;Parkinson's Disease Quality of Life Questionnaire(PDQ-39)was used to evaluate the quality of life of patients;the diagnostic criteria for depression and anxiety in Parkinson disease were used for the diagnosis of depression and anxiety in patients with Parkinson disease;Hamilton Depression Scale(HAMD)and Hamil-ton Anxiety Scale(HAMA)were used to assess the severity of depression and anxiety.Results Among the 93 patients with Parkinson disease,the prevalence rates of depression and anxiety were 59.1%and 44.1%,respectively.There were signifi-cant differences between the depression group and the non-depression group in the somatization,despair,cognitive impairment,block factor,and day-night changes of anxiety,but there were no significant differences in sleep disorders and body weight be-tween the two groups.The depression group had significantly higher PDQ-39 scores than the non-depression group,and the anxiety group had significantly higher PDQ-39 scores than the non-anxiety group.Depressive state was negatively correlated with folate and was positively correlated with blood homocysteine.Anxiety state was positively correlated with H-Y stage and UPDRS Ⅲ score.Conclusion There are relatively high prevalence rates of depression and anxiety in patients with Parkinson disease in Tibetan plateau area,which significantly affects the quality of life of patients.关键词
帕金森病/高原/抑郁/焦虑/生活质量Key words
Parkinson disease/Plateau/Depression/Anxiety/Quality of life分类
临床医学引用本文复制引用
王壹,王琳,冉冉,季士勇,赵玉华,张梦雨,唐茹萱,次旦卓嘎,袁晶,米玛顿珠..西藏地区帕金森病患者焦虑抑郁状态及对生活质量的影响[J].中风与神经疾病杂志,2025,42(2):104-108,5.基金项目
西藏自治区自然科学基金组团式援藏医学项目资助[XZ2023ZR-ZY20(Z)] （Z）
中国医学科学院中央级公益性科研院所基本科研项目(2022-RW320-04) （2022-RW320-04）
