中风与神经疾病杂志2025，Vol.42Issue(2)：109-114,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0022
女性帕金森病患者异动症临床特征和危险因素分析
Clinical features of dyskinesis and related risk factors in female patients with Parkinson disease
摘要
Abstract
Objective To investigate the clinical features of dyskinesia and related risk factors in female patients with Parkinson disease(PD).Methods A cross-sectional study was conducted among the female patients who met the di-agnostic criteria for PD at the outpatient service of PD in Aerospace Center Hospital,and demographic data and clinical data were collected and compared between groups,including levodopa equivalent daily dose(LEDD),Unified Parkinson's Disease Rating Scale-Ⅲ(UPDRS-Ⅲ),UPDRS-Ⅳ,scores of non-motor symptoms(cognition and depression),presence or ab-sence of dyskinesia,and single levodopa dose(LD)during the onset of dyskinesia.A binary logistic regression analysis was used to investigate the influencing factors for dyskinesia in female patients with PD.Results A total of 146 female PD patients were enrolled,among whom 30 patients had dyskinesia,with an incidence rate of 20.5%.Compared with the non-dyskinesia group in terms of clinical features,the dyskinesia group had a significantly younger age of onset[(54.3±12.5)years vs(62.7±10.0)years,P<0.001],a significantly longer disease duration[(9.9±3.7)years vs(4.5±3.7)years,P<0.001],a signifi-cantly higher severity of disease[H-Y stage:(2.65±0.58)vs(2.35±0.83),P=0.03],a significantly longer duration of LD administration[(7.5±3.2)years vs(3.2±2.6)years,P<0.001],a significantly higher LEDD[(703.2±203.9)mg vs(442.1±226.3)mg,P<0.001],and significantly lower body weight[(54.1±8.2)kg vs(60.0±8.7)kg,P=0.001]and BMI[(20.9±3.1)kg/m2 vs(23.4±3.1)kg/m2,P<0.001].The multivariate logistic regression analysis showed that high BMI(OR=0.770,P=0.005)was a protective factor against dyskinesia in female PD patients,while long disease duration(OR=1.304,P=0.001)and high LEDD(OR=1.003,P=0.012)were risk factors for dyskinesia.Conclusion There is a relatively high incidence rate of dyskinesia in female PD patients,which should be taken seriously in clinical practice,and high BMI is a protective factor,while long disease duration and high LEDD are risk factors for dyskinesia in female PD patients.关键词
帕金森病/女性/异动症/危险因素/左旋多巴Key words
Parkinson disease/Female/Dyskinesia/Risk factors/Levodopa分类
临床医学引用本文复制引用
赵静,王彦宏,陈佳琦,马少辰,李继来,王培福,杜继臣,冯涛,万志荣..女性帕金森病患者异动症临床特征和危险因素分析[J].中风与神经疾病杂志,2025,42(2):109-114,6.基金项目
航天中心医院科研基金项目(YN202403) （YN202403）
