中风与神经疾病杂志2025，Vol.42Issue(2)：126-132,7.DOI:10.19845/j.cnki.zfysjjbzz.2025.0025
线粒体生物发生异常与帕金森病的相关性
Relationship between mitochondrial biogenesis abnormalities and Parkinson disease
摘要
Abstract
Parkinson disease is a neurodegenerative disorder with motor and cognitive impairments as the main clini-cal symptoms.The disease is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of Lewy bodies,which are eosinophilic inclusions composed of α-synuclein,in the remaining dopaminergic neurons.The disease predominantly affects middle-aged and elderly individuals.Oxidative stress caused by mitochondrial dysfunction can lead to the loss of dopaminergic neurons,so mitochondrial dysfunction is considered as the main cause of Parkinson disease.Mitochondrial biogenesis has an important effect on the function of mitochondria.There-fore,abnormality of the regulation system of mitochondrial biogenesis is closely related to the occurrence and development of Parkinson disease.This review focuses on the regulatory mechanism of mitochondrial biogenesis control system and aims to provide promising therapeutic targets for Parkinson disease.关键词
帕金森病/线粒体/线粒体生物发生/PGC-1α/α-突触核蛋白/多巴胺能神经元Key words
Parkinson disease/Mitochondria/Mitochondrial biogenesis/PGC-1α/α-synuclein/Dopa-minergic neurons分类
临床医学引用本文复制引用
仇晓蕊,张译丹,仇海滨,杨国锋..线粒体生物发生异常与帕金森病的相关性[J].中风与神经疾病杂志,2025,42(2):126-132,7.基金项目
河北省自然科学基金(H2022206231) （H2022206231）
河北省重点研发计划项目(21377745D) （21377745D）
