中风与神经疾病杂志2025，Vol.42Issue(2)：133-136,4.DOI:10.19845/j.cnki.zfysjjbzz.2025.0026
帕金森病伴周围神经病变的机制
Mechanisms of Parkinson disease with peripheral neuropathy
摘要
Abstract
Parkinson disease(PD)is the second most prevalent neurodegenerative disorder and predominantly im-pacts the extrapyramidal system.This condition arises from the degeneration of the dopaminergic nigrostriatal pathway.In recent years,studies have shown that PD pathology and lesions are not limited to the center nervous system,and that PD is a systemic and multisystem disease.The concurrence of PD with peripheral neuropathy(PN)has been increasingly ac-knowledged,although its pathogenesis remains elusive.The motor symptoms in PD patients often mask the symptoms of PN,leading to relatively low clinical recognition of PD coexisting with PN.This poses challenges in the clinical diagnosis and treatment of PD.This review comprehensively summarize the pathogenesis of PD coexisting with PN.关键词
帕金森病/周围神经病变/机制Key words
Parkinson disease/Peripheral neuropathy/Mechanism分类
临床医学引用本文复制引用
张厚文,朱虹,李春荣,王钟秀,吴忧..帕金森病伴周围神经病变的机制[J].中风与神经疾病杂志,2025,42(2):133-136,4.基金项目
浙江省卫生健康科技计划(2021KY841) （2021KY841）
