中风与神经疾病杂志2025，Vol.42Issue(2)：137-142,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0027
脑白质病变对帕金森病相关症状的影响
Effect of cerebral white matter lesion on the symptoms of Parkinson disease
赵爱 1宋逍 1李星君 1白晶1
作者信息
- 1. 吉林大学白求恩第一医院神经内科,吉林 长春 130021
- 折叠
摘要
Abstract
Parkinson's disease(PD)is a common neurodegenerative disease with a high incidence rate in the el-derly population,and its complex pathogenesis involves α-synuclein misfolding and aggregation,mitochondrial dysfunc-tion,neuroinflammation,and oxidative stress,resulting in different impairments of motor and non-motor symptoms and a bad influence on the quality of life of patients.White matter lesion(WML)is a neurodegenerative disease caused by dam-age to myelin sheath tissue in the central nervous system of the brain,with the pathogenesis of endothelial damage,hypo-perfusion of brain white matter,and impairment of blood-brain barrier.WML causes varying degrees of impairment in pos-tural instability,gait disturbance,and motor retardation in PD patients and exerts a certain degree of negative effects on cognitive function and sleep,anxiety,depression,and autonomic nervous function in PD patients.This article reviews the pathogenesis of PD and WML and the damage or influence of WML on the motor and non-motor symptoms of PD,in order to elaborate on the association between WML and PD.关键词
帕金森病/脑白质病变/运动症状/非运动症状Key words
Parkinson disease/White matter lesion/Motor symptoms/Non-motor symptoms分类
临床医学引用本文复制引用
赵爱,宋逍,李星君,白晶..脑白质病变对帕金森病相关症状的影响[J].中风与神经疾病杂志,2025,42(2):137-142,6.
