中国当代儿科杂志2025，Vol.27Issue(3)：315-320,6.DOI:10.7499/j.issn.1008-8830.2408085
2022-2023年成都市0～6岁儿童侵袭性非伤寒沙门菌肠炎的临床和药敏特征
Clinical and drug sensitivity characteristics of invasive non-typhoidal Salmonella enteritis in children aged 0-6 years in Chengdu,China,2022-2023
杨玲蓉 1周春婷 2郭静 1吴雨露 1熊复1
作者信息
- 1. 四川省妇女儿童医院/成都医学院附属妇女儿童医院儿童消化科,四川 成都 610000
- 2. 温州医科大学第二临床医学院儿科,浙江 温州 325000
- 折叠
摘要
Abstract
Objective To investigate the clinical characteristics and drug resistance profile of invasive non-typhoidal Salmonella(NTS)enteritis in children in Chengdu,China,providing a reference for rational drug use and empirical treatment in clinical practice.Methods A retrospective analysis was conducted on the clinical data of 130 children with invasive bacterial enteritis due to NTS identified by fecal bacterial culture and the results of drug sensitivity tests for NTS in Chengdu from January 2022 to December 2023.Results NTS infections were mainly observed from April to September(113 cases,86.9%),with a peak in August(36 cases,27.7%).Children aged<36 months accounted for 86.2%(112/130)of all cases,and the main symptoms were diarrhea(130 cases,100%),fever(123 cases,94.6%),and hematochezia(112 cases,86.2%).The 130 NTS isolates exhibited a sensitivity rate of 64.6%to ceftriaxone and 63.8%to cefotaxime,and a sensitivity rate of>90.0%to piperacillin-tazobactam and nitrofurantoin(nitrofurans).The detection rate of multidrug-resistant strains was 48.5%(63/130),and the clinical efficacy of third-generation cephalosporins used in 38 patients(29.2%)was inconsistent with the results of drug sensitivity tests.Conclusions The peak of invasive NTS enteritis in children aged 0-6 years occurs in August in the Chengdu area,with a relatively high incidence rate in children aged<36 months.The situation of drug resistance is severe for NTS,and piperacillin-tazobactam may be an effective option for treating multidrug-resistant NTS infections in children,while nitrofuran antibiotics might be used to treat such infections.关键词
肠炎/沙门菌/临床特点/药敏/儿童Key words
Enteritis/Salmonella/Clinical characteristic/Drug sensitivity/Child引用本文复制引用
杨玲蓉,周春婷,郭静,吴雨露,熊复..2022-2023年成都市0～6岁儿童侵袭性非伤寒沙门菌肠炎的临床和药敏特征[J].中国当代儿科杂志,2025,27(3):315-320,6.
