非洲猪瘟弱毒疫苗效力评价研究进展OA

African swine fever(ASF)is a severe infectious disease caused by African swine fever virus(ASFV)infection.Current ASF vaccines under development were still difficult to consider absolute safety and reliable efficacy.Here,the reported research data related to ASF attenuated vaccines were summarized and analyzed from the aspects of challenge doses and routes,post-challenge evaluation indicators,etc.The results showed that the effectiveness of ASF attenuated vaccines was mainly evaluated by means of immune challenge;the intramuscular injection dose was mostly 102-104 HAD50/TCID50,while the doses for oral and nasal vaccination similar to natural infection varied greatly depending on different infection routes;body temperature,clinical manifestation,death,viremia and detoxification level were often used as the indicators to evaluate post-vaccination challenge,and clinical indicators were scientifically displayed based on clinical scoring standard.At the level of technology,vaccine challenge test simulating natural infection routes should be further explored for efficacy evaluation on ASF attenuated vaccines in the future.