摘要
Abstract
Objective To study the relevant factors affecting the occurrence of adjacent vertebral fractures in women with osteoporotic vertebral compression fractures after conservative treatments.Methods A total of 98 elderly female patients diag-nosed with osteoporotic vertebral compression fractures and treated from January 2020 to January 2022 were retrospectively analyzed.The average age was(73.05±7.38)years old.Based on the follow-up results after two years of injury,the patients were divided into the adjacent vertebral fracture group(24 cases)and the non-adjacent vertebral fracture group(74 cases).The following factors were recorded for each patient:age,initial bone density,follow-up bone density,bone density changes,initial VAS score,degree of fracture compression,presence of old fractures,use of zoledronic acid,use of parathyroid hormone analogs,occurrence of complications,and further compression of the affected vertebrae.Univariate and multivariate Logistic regression analyses were performed to analyze the associated risk factors.Results Univariate analysis revealed that in elderly women undergoing conservative treatment for osteoporotic vertebral compression fractures,the degree of fracture compression,follow-up bone density,changes in bone density,use of zoledronic acid,and use of parathyroid hormone analogs were statisti-cally significant(P＜0.05).Multivariate Logistic regression analysis demonstrated that the degree of fracture compression 95％CI(0.040,0.571),P=0.005,OR=0.151,changes in bone density 95％CI(1.264,1 360.732),P=0.036,OR=41.477,and use of parathyroid hormone analogs 95％CI(1.638,31.625),P=0.009,OR=7.196 were risk factors affecting the occurrence of adjacent vertebral fractures following vertebral compression fractures in elderly women with osteoporosis.Conclusion The degree of fracture compression,changes in bone density,and the use of parathyroid hormone analogs are factors influencing the occur-rence of adjacent vertebral fractures following vertebral compression fractures in elderly women with osteoporosis.For patients with mild compression fractures(grade I),conservative treatment can be achieved by intensifying anti-osteoporosis therapy and using parathyroid hormone analogs.关键词
骨质疏松/椎体压缩性骨折/邻近椎体骨折/保守治疗/危险因素Key words
Osteoporosis/Vertebral compression fractures/Adjacent vertebral fractures/Conservative treatment/Risk factors分类
临床医学
