中国骨伤2025，Vol.38Issue(2)：211-216,6.DOI:10.12200/j.issn.1003-0034.20240312
维生素D及其受体基因多态性与骨结核易感性的研究进展
Research progress on polymorphism of vitamin D and its receptor gene and susceptibility to bone tuberculosis
摘要
Abstract
Bone tuberculosis is one of the main lesions of extrapulmonary tuberculosis,and the affected site shows local pain and limited movement,and the severe patients face a higher risk of teratogenicity and disability.Especially in the context of the increasing spread of multidrug-resistant tuberculosis,it is particularly urgent to seek innovative treatment options.In re-cent years,vitamin D plays an important role in the prevention and treatment of bone tuberculosis,and the mechanism of action has been continuously explored.At the same time,vitamin D receptor gene polymorphism has also been found to be closely re-lated to the susceptibility and risk of bone tuberculosis.This article reviewed the relationship between vitamin D and its recep-tor gene polymorphisms and the susceptibility to bone tuberculosis.It was found that vitamin D deficiency increased the sus-ceptibility to bone tuberculosis in both adults and children,and multiple genotypes of vitamin D receptor had an effect on the susceptibility to bone tuberculosis,especially Fok Ⅰ genotype.It may also be one of the reasons for the increase in the number of bone tuberculosis.Through the study of the relationship between vitamin D and its receptor gene polymorphism and the sus-ceptibility to bone tuberculosis,some factors inducing bone tuberculosis can be avoided,and related new drugs can be more targeted,such as vitamin D supplements,gene receptor related antagonists,etc.To provide more systematic and targeted strate-gies for the prevention and treatment of bone tuberculosis.关键词
骨结核/维生素D/维生素D受体/易感性/综述文献Key words
Bone tuberculosis/Vitamin D/Vitamin D receptor/Susceptibility/Review literature分类
医药卫生引用本文复制引用
刘鑫锋,张彦军,李军杰,杨军,田宏晶..维生素D及其受体基因多态性与骨结核易感性的研究进展[J].中国骨伤,2025,38(2):211-216,6.基金项目
2021年甘肃省财政转移支付地方项目(编号:20210140305) （编号:20210140305）
2023年甘肃省卫生行业项目(编号:GSWSKY2023-27) （编号:GSWSKY2023-27）
2022年甘肃省科技计划项目(编号:22JR5RA624) （编号:22JR5RA624）
2016年兰州市科技计划项目(编号:2016-3-114)Local project of financial transfer payment of Gansu Province in 2021(No.20210140305) （编号:2016-3-114）
