中国临床药理学与治疗学2025，Vol.30Issue(2)：146-158,13.DOI:10.12092/j.issn.1009-2501.2025.02.001
靶向结合免疫激活治疗CLDN18.2阳性胃癌的研究进展
Research progress on targeted therapy combined with immune-acti-vating strategies in CLDN18.2-positive gastric cancer
摘要
Abstract
Claudin 18 isoform 2(Claudin18.2,CLDN18.2)is a crucial structural protein involved in cell-cell tight junctions.While its expression is limit-ed in normal tissues,it is specifically overexpressed in malignant tumors such as gastric cancer,pancre-atic cancer,and esophageal cancer,making it a promising therapeutic target for cancer treatment.Recent advances in CLDN18.2-targeted therapies have been encouraging,and studies suggest that CLDN18.2-positive gastric cancer may possess a unique immune microenvironment.This raises the potential for combining targeted therapies with im-mune activation to achieve synergistic effects,po-tentially improving treatment outcomes for pa-tients with advanced gastric cancer.This review will focus on the immune microenvironment character-istics of CLDN18.2-positive gastric cancer and sum-marize the current research and clinical trial prog-ress in targeted therapies combined with immune activation for this specific cancer type.关键词
胃癌/Claudin18.2/肿瘤免疫微环境/靶向治疗Key words
gastric cancer/Claudin18.2/tumor immune microenvironment/targeted therapy分类
临床医学引用本文复制引用
聂扬,汪越,魏嘉..靶向结合免疫激活治疗CLDN18.2阳性胃癌的研究进展[J].中国临床药理学与治疗学,2025,30(2):146-158,13.基金项目
国家自然科学基金青年项目(82403862) （82403862）
南京市卫生科技发展项目(YKK23084) （YKK23084）
