中国临床药理学与治疗学2025，Vol.30Issue(2)：272-281,10.DOI:10.12092/j.issn.1009-2501.2025.02.015
柚皮苷对心血管疾病的药理作用研究进展
Progress in the pharmacological effects of naringin on cardiovascular diseases
摘要
Abstract
Naringin is a flavonoid compound with a wide range of biological and pharmacologi-cal activities,which can be used in treating tumor,diabetes,neurodegenerative diseases,cardiovascu-lar diseases,metabolic syndrome,etc.Among them,the application of naringin in cardiovascular diseases has attracted the attention of many re-searchers.This article mainly reviews the role of naringin in cardiovascular disease(regulating blood lipids,anti atherosclerosis,lowering blood pres-sure,inhibiting myocardial hypertrophy,anti myo-cardial infarction,protecting myocardial ischemia/reperfusion injury,reducing myocardial ischemia/reperfusion injury and improving pulmonary arteri-al hypertension),the protective effect on cardiotox-icity,and the signal pathways in cardiovascular dis-ease(PI3K-Akt-mTOR,p-eNOS/p-Akt/p-ERK,miR-126/GSK-3 β/β-Catenin),clinical trials,etc.This pa-per is expected to review the current research sta-tus of naringin in cells and animal models so as to reveal its clinical application prospects and provide reference for further research in related fields.关键词
柚皮苷/动脉粥样硬化/缺血/再灌注/心肌肥厚/心脏毒性Key words
naringin/atherosclerosis/ischemia/reperfusion/myocardial hypertrophy/cardiotoxicity分类
医药卫生引用本文复制引用
刘丹,苗加伟,谭子豪,何春瑶,赵明珠,何秀贞..柚皮苷对心血管疾病的药理作用研究进展[J].中国临床药理学与治疗学,2025,30(2):272-281,10.基金项目
重庆市教育委员会科学技术研究项目(KJQN202202704) （KJQN202202704）
重庆市卫生和计划生育委员会中医药科技项目(ZY201703077) （ZY201703077）
重庆三峡医药高等专科学校自然科学重大项目(XJ2022003103) （XJ2022003103）
重庆三峡医药高等专科学校重点实验室项目(Sys20210009) （Sys20210009）
