中国临床医学影像杂志2025，Vol.36Issue(3)：179-183,5.DOI:10.12117/jccmi.2025.03.006
非小细胞肺癌患者18F-FDG PET/CT参数与癌组织Ki-67、PD-L1表达的关系
Relationship between 18F-FDG PET/CT parameters and Ki-67,PD-L1 in patients with non-small cell lung cancer
摘要
Abstract
Objective:To explore the relationship between fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)parameters and tumor proliferation antigen(Ki-67),programmed death ligand 1(PD-L1)in patients with non-small cell lung cancer(NSCLC).Methods:A total of 72 patients with NSCLC admitted to the hospital were enrolled between September 2021 and April 2024.18F-FDG PET/CT parameters,clinical staging,tumor diameter and differentiation degree in patients with different pathological characteristics were compared.The expressions of Ki-67 and PD-L1 were detected by immunohistochemistry.According to Ki-67 expression,patients were divided into high-expression Ki-67 group(41 cases,≥50%)and low-expression Ki-67 group(31 cases,<50%,and 18F-FDG PET/CT parameters(maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),total lesion glycolysis(TLG))in the two groups were compared.According to PD-L1 expression,patients were divided into negative group(13 cases),low-expression PD-L1 group(27 cases)and high-expression PD-L1 group(32 cases),and 18F-FDG PET/CT parameters in three groups were compared.The correlation between 18F-FDG PET/CT parameters and Ki-67,PD-L1 was analyzed by Spearman.Results:SUVmax,MTV,TLG and tumor diameter in patients with lung squamous cell carcinoma were higher than those with lung adenocarcinoma(P<0.05),but there was no significant difference in TNM staging and differentiation degree(P>0.05).SUVmax,MTV and TLG in high-expression Ki-67 group were higher than those in low-expression Ki-67 group(P<0.05).Spearman analysis showed that SUVmax,MTV and TLG were positively correlated with Ki-67(t=0.415,0.422,0.409,P<0.05).SUVmax,MTV and TLG were gradually decreased in high-expression PD-L1 group,low-expression PD-L1 group and negative group(P<0.05).Spearman analysis showed that SUVmax,MTV and TLG were positively correlated with PD-L1(t=0.421,0.406,0.432,P<0.05).Conclusion:18F-FDG PET/CT parameters are positively correlated with Ki-67 and PD-L1 in NSCLC patients.Clinically,expression status of Ki-67 and PD-L1 can be determined according to 18F-FDG PET/CT parameters.关键词
癌,非小细胞肺/正电子发射断层显像计算机体层摄影术/氟脱氧葡萄糖F18Key words
Carcinoma,Non-Small-Cell Lung/Positron Emission Tomography Computed Tomography/Fluorodeoxyglucose F18分类
医药卫生引用本文复制引用
宋烈晶,徐海青,詹必成,张垒,胡玉华..非小细胞肺癌患者18F-FDG PET/CT参数与癌组织Ki-67、PD-L1表达的关系[J].中国临床医学影像杂志,2025,36(3):179-183,5.基金项目
安徽医科大学科研基金资助项目(编号:2020xkj240). （编号:2020xkj240）
