摘要
Abstract
Objective To observe the cosmetic effect of acellular allogeneic dermis combined with autologous split-thickness skin graft on hyperplastic scar.Methods 64 patients with hypertrophic scar admitted to the author's hospital from October 2019 to December 2022 were selected and divided into control group and experimental group according to the random number table method,with 32 cases in each group.The control group was treated with autologous skin graft,and the experimental group was treated with acellular allogeneic dermis combined with autologous skin graft.Postoperative recovery status(skin graft survival rate,wound healing time),pain degree[visual analogue scale(VAS)]before surgery and at 1,2,3 and 7 days after surgery,collagen fiber indicators(type Ⅰ collagen fiber,type Ⅲ collagen fiber,type Ⅰ collagen fiber/type Ⅲ collagen fiber)and scar status[Vancouver scar scale(VSS)]before surgery and at 3 months after surgery were compared between the two groups of patients.Results 14 days after surgery,there was no significant difference in the survival rate of grafts between the two groups(P＞0.05),and the wound healing time in the observation group was shorter than that in the control group(P＜0.05).There was no significant difference in VAS score between the two groups before surgery and 1,2 and 3 days after surgery(P＞0.05),but the VAS score of the observation group was lower than that of the control group 7 days after surgery(P＜0.05).The type Ⅰ collagen fiber content,type Ⅲ collagen fiber content,the ratio of the two contents and VSS in the two groups were declined at 3 months after surgery compared to before surgery,and the indicators were lower in experimental group than those in control group(P＜0.05).Conclusion Acellular allogenic dermis combined with autologous split-thickness skin graft can effectively remove hypertrophic scar,relieve pain,inhibit collagen fiber regeneration,and thus improve scar status,which is worthy of clinical recommendation.关键词
脱细胞异体真皮/自体皮肤移植/增生性瘢痕/Ⅰ型胶原纤维/Ⅲ型胶原纤维Key words
acellular allogenic dermis/autologous skin graft/hypertrophic scar/type Ⅰ collagen fiber/type Ⅲ collagen fiber分类
医药卫生
