摘要
Abstract
Objective To explore the effect of intense pulsed light combined with tranexamic acid on chloasma and its influence on skin barrier function.Methods Sixty-two patients with chloasma in the author's hospital from February 2021 to February 2023 were randomly divided into control group(n=31)and study group(n=31).The control group was given tranexamic acid,and the study group was given tranexamic acid+intense pulsed light.The curative effect,patient satisfaction and skin barrier function[transepidermal water loss(TEWL),stratum corneum water content,epidermal oil content],melasma area severity index(MASI),physician global assesment(PGA)and Hamilton depression scale(HAMD)before and after treatment for 24 weeks were statistically compared.Results Compared with the control group(67.74%,64.52%),the treatment efficiency and patient satisfaction in the study group were higher(90.32%,87.10%)(P＜0.05).Compared with the control group,the scores of MASI and HAMD in the study group were lower after treatment(P＜0.05).Compared with the control group,after treatment,the stratum corneum water content and epidermal oil content in the study group were higher,and the TEWL was lower(P＜0.05).The PGA score of the study group was better than that of the control group(P＜0.05).Conclusion Intense pulsed light plus tranexamic acid can improve the therapeutic effect of chloasma,which can improve patients'depression,promote the repair of skin barrier function and improve patients'treatment satisfaction.关键词
黄褐斑/皮肤屏障功能/强脉冲光/氨甲环酸/疗效Key words
chloasma/skin barrier function/intense pulsed light/tranexamic acid/therapeutic effect分类
临床医学
