摘要
Abstract
Objective To explore the effect of 1 064 nm picosecond laser combined with tranexamic acid on patients'aesthetic satisfaction and symptoms.Methods From January 2020 to February 2023,75 patients with chloasma in Cangzhou Maternal and Child Health Hospital of Hebei Province were selected and divided into the control group(tranexamic acid treatment,37 cases)and the observation group(control group+1 064 nm picosecond laser treatment,38 cases)according to the treatment methods.Both groups were treated continuously for 6 months.The clinical efficacy,aesthetic satisfaction after 6 months of treatment,scores of area and severity of chloasma(MASI)at different time points,levels of serum lipid oxide(LPO),glutathione peroxidase(GSH-Px),melatonin(MSH),cyclooxygenase-2(COX-2)and scores of Melasma quality of life score(MELASQOL),skin lesion area and skin lesion color before treatment and 6 months after treatment,and incidence of adverse reactions during the study period were compared between the control group and the observation group.Results After 6 weeks of treatment,the total clinical effective rate in the observation group was 97.37%higher than that in the control group(75.68%)(P＜0.05).The results of the control group and the observation group showed that the MASI score,serum LPO,MSH,COX-2 levels,MELASQOL,lesion area and color score of the two groups decreased gradually after 1-6 months of treatment,while the observation group was lower than the control group,while the serum GSH-Px level increased,while the observation group was higher than the control group(P＜0.05).The results of the control group and the observation group showed that the overall satisfaction rate of the latter was higher after 6 months of treatment(P＜0.05).The results of the control group and the observation group showed that there was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion 1 064 nm picosecond laser combined with tranexamic acid in the treatment of chloasma was helpful to relieve the symptoms and skin lesions of patients with chloasma,inhibit oxidative stress reaction,reduce pigmentation,and further improve the quality of life.The curative effect was remarkable,and patients had high aesthetic satisfaction and good safety.关键词
黄褐斑/皮秒激光/氨甲环酸/美观满意度Key words
chloasma/picosecond laser/tranexamic acid/aesthetic satisfaction分类
医药卫生
