摘要
Abstract
Objective To explore the effect of platelet-rich fibrin(PFR)combined with minimally invasive surgical technique(MIST)in the treatment of vertical bone defect in periodontitis.Methods A total of 96 patients with periodontitis vertical bone defects admitted to the hospital from January 2021 to December 2022 were divided into a control group and a study group by random number table method,with 48 cases in each group.The control group was treated with MIST,and the study group was treated with PRF combined with MIST.The clinical efficacy and adverse reactions of the two groups were observed and compared,as well as the changes of periodontal measurement indexes,tumor necrosis factor-ɑ(TNF-α),C-reactive protein(CRP),and interleukin-6(IL-6)levels before and 6 months after surgery were compared.Results The total effective rate of the study group(95.83%)was higher compared with control group(83.33%)(P＜0.05).At 6 months after operation,the probing depth(PD),Mazza bleeding index(BI),clinical attachment loss(CAL),gingival recession depth,and alveolar bone defect depth in the two groups were lower than those before operation,and the PD,CAL,gingival recession depth,and alveolar bone defect depth in the study group were lower compared with control group(P＜0.05).At 6 months after operation,the levels of CRP,TNF-α and IL-6 in the two groups were lower compared with before operation,and the study group were lower compared with control group(P＜0.05).The incidence of side reactions in the study group(4.16%)was lower compared with control group(18.75%)(P＜0.05).Conclusion PRF combined with MIST is effective in the treatment of vertical bone defects in periodontitis,which is beneficial to improve periodontal indexes,inhibit inflammatory response,and has high safety,which is worthy of clinical application.关键词
富血小板纤维蛋白/微创外科技术/牙周炎垂直骨缺损/牙周引导组织再生术Key words
platelet-rich fibrin/minimally invasive surgical techniques/periodontitis vertical bone defect/periodontal guided tissue regeneration分类
医药卫生
